Mazza Alfredo, Bossone Eduardo, Gianicolo Elena, Mazza Felice, Distante Alessandro
Istituto di Cardiologia, Università di Catania.
Monaldi Arch Chest Dis. 2003 Dec;60(4):283-7.
The current body of evidence suggests that Chlamydia Pneumoniae (CP) infections may play a role in the development and maintenance of atherosclerosis process and related clinical complications.
In our study we assess the association between seropositivity of CP antibody IgG to common carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus (DM). One hundred thirty DM patients (mean age 53 +/- 10 years, 70 female) were enrolled for study. Serum CP IgG antibody were detected by microimmunofluorescent technique; IMT and plaques or stenosis in the common carotid were assessed by ultrasonography.
In univariate analysis common carotid IMT was significantly associated with age (P>0.00001), body mass index [(BMI) P>0.0003], acid uric (P>0.004), systolic blood pressure (P>0.03), glycemia (P>0.03) and total cholesterol (P>0.04). No significant correlation was found between CP antibody IgG titer and IMT. In multiple regression analysis only age (P>0.0001), uric acid (P>0.03), glycemia and BMI (P>0.05) were independently associated with IMT.
Lack of association was found between CP seropositivity and common carotid IMT in patients with DM.
目前的证据表明，肺炎衣原体（CP）感染可能在动脉粥样硬化进程及相关临床并发症的发生和发展中起作用。
在我们的研究中，我们评估了2型糖尿病（DM）患者中CP抗体IgG血清阳性与颈总动脉内膜中层厚度（IMT）之间的关联。130例DM患者（平均年龄53±10岁，女性70例）纳入研究。采用微量免疫荧光技术检测血清CP IgG抗体；通过超声检查评估颈总动脉的IMT、斑块或狭窄情况。
单因素分析中，颈总动脉IMT与年龄（P>0.00001）、体重指数[（BMI）P>0.0003]、尿酸（P>0.004）、收缩压（P>0.03）、血糖（P>0.03）和总胆固醇（P>0.04）显著相关。未发现CP抗体IgG滴度与IMT之间存在显著相关性。多因素回归分析中，仅年龄（P>0.0001）、尿酸（P>0.03）、血糖和BMI（P>0.05）与IMT独立相关。
在DM患者中，未发现CP血清阳性与颈总动脉IMT之间存在关联。
