白塞病发病机制与治疗的新见解。

New insights into the pathogenesis and therapy of Behçet's disease.

作者信息

Arayssi Thurayya, Hamdan Ayad

机构信息

Department of Internal Medicine, American University of Beirut-Medical Center, PO Box 11-0236, Riad El Solh 11072020, Beirut, Lebanon.

出版信息

Curr Opin Pharmacol. 2004 Apr;4(2):183-8. doi: 10.1016/j.coph.2003.10.009.

DOI:10.1016/j.coph.2003.10.009

PMID:15063364

Abstract

Behçet's disease is a chronic multisystem inflammatory disease characterized by the predominance of Th1 cytokines. The human leukocyte antigen-B 51 gene is associated with the disease in several ethnic groups, but it is not certain whether it is the susceptibility gene or if it is in linkage disequilibrium with other genes. Recent studies of polymorphisms of neighboring, as well as distant, genes to human leukocyte antigen-B 51 are helpful in elucidating the pathogenesis of the disease and could have therapeutic implications.

摘要

白塞病是一种以Th1细胞因子为主导的慢性多系统炎症性疾病。人类白细胞抗原-B51基因在多个种族群体中与该疾病相关，但尚不确定它是否为易感基因，或者它是否与其他基因处于连锁不平衡状态。最近对人类白细胞抗原-B51邻近基因以及远距离基因多态性的研究，有助于阐明该疾病的发病机制，并可能具有治疗意义。