Weng Jing-Ru, Ko Horng-Huey, Yeh Ting-Li, Lin Hsien-Cheng, Lin Chun-Nan
School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
Arch Pharm (Weinheim). 2004 Apr;337(4):207-12. doi: 10.1002/ardp.200300841.
Two new arylnaphthalide lignans, procumphthalide A (1) and 4-O-beta-D-glucopyranosyl-(1"'-->2")-beta-D-apiofuranosyldiphyllin, named procumbenoside B (2), along with cilinaphthalide B (3) and several other known compounds were isolated from the methanolic extracts of Justicia procumbens. By using NMR and other spectral methods, the structures of 1 and 2 were elucidated. Cilinaphthalide B (3), justicidin A (4), and taiwan E methyl ether (5) were shown to have an antiplatelet effect in human plateletrich plasma. In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration-dependent manner, with an IC(50) value of about 27.6 microM.
从爵床的甲醇提取物中分离出两种新的芳基萘内酯木脂素，前胡酞内酯A（1）和4-O-β-D-吡喃葡萄糖基-（1'''→2''）-β-D-芹菜呋喃糖基双叶豆素，命名为前胡贝诺甙B（2），以及水苏萘内酯B（3）和其他几种已知化合物。通过核磁共振（NMR）和其他光谱方法阐明了1和2的结构。水苏萘内酯B（3）、爵床素A（4）和台湾E甲醚（5）在人富血小板血浆中显示出抗血小板作用。在人枸橼酸化富血小板血浆（PRP）中，5对肾上腺素诱导的血小板聚集呈浓度依赖性强抑制作用，IC50值约为27.6微摩尔。
