Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry & Chemical Engineering of Guangxi Normal University, Guilin 541004, People's Republic of China.
J Org Chem. 2013 Mar 15;78(6):2742-5. doi: 10.1021/jo3026803. Epub 2013 Feb 13.
A novel and efficient Cu(OTf)2-catalyzed sp(3)-sp(2) C-C bond formation reaction through the direct coupling of propargylic alcohols with terminal alkenes has been realized under mild conditions. The reaction is tolerant to air and is atom-economical, in accordance with the concept of modern green chemistry. The present protocol provides an attractive approach to a diverse range of 1,4-enynes in high to excellent yields.
一种新型、高效的铜（OTf）2 催化的 sp(3)-sp(2) C-C 键形成反应，通过炔丙醇与末端烯烃的直接偶联，在温和条件下实现。该反应对空气具有耐受性，且原子经济性高，符合现代绿色化学的理念。本方案为各种 1,4-烯炔提供了一种有吸引力的合成途径，产率高至优秀。
