Farahati Jamshid, Geling Markus, Mäder Uwe, Mörtl Markus, Luster Markus, Müller Justus G, Flentje Michael, Reiners Christoph
Department of Nuclear Medicine, University of Wuerzburg, Germany.
Thyroid. 2004 Feb;14(2):141-7. doi: 10.1089/105072504322880382.
A population-based registry (PBR) in Lower Frankonia in southern Germany was conducted to evaluate the changes of incidence and prognosis of thyroid carcinoma (TC) in this area.
The study comprised 476 patients with differentiated thyroid carcinoma (DTC) from Lower Franconia (1.3 x 10(6) inhabitants) registered between 1981 and 1995 at the Regional Tumor Center. The incidence was assessed with respect to gender, age, histology, tumor stage, lymph node involvement and distant metastases in 5-year intervals (1981-1985, 1986-1990, and 1991-1995).
An increasing rate of papillary thyroid carcinoma PTC and a decreasing rate of follicular thyroid carcinoma (FTC) were observed over the three time periods (1981-1985, 1986-1990, and 1991-1995). The overall incidence revealed no significant change with time for both females from 3.22 to 3.25 and 3.73 and males (1.07 to 1.54 and 1.69) between the three time periods. There was a significant improvement in outcome of patients with DTC with respect to life expectancy.
Iodine prophylaxis does influence the distribution of the histologic types of thyroid cancer and leads to an increase in the ratio of papillary versus follicular carcinoma. Our study supports the hypothesis that the benefits of correcting iodine deficency outweigh the risks of iodine supplementation.
在德国南部下弗兰肯地区开展了一项基于人群的登记研究（PBR），以评估该地区甲状腺癌（TC）的发病率和预后变化。
该研究纳入了1981年至1995年间在地区肿瘤中心登记的476例来自下弗兰肯地区（130万居民）的分化型甲状腺癌（DTC）患者。按性别、年龄、组织学类型、肿瘤分期、淋巴结受累情况和远处转移情况，以5年为间隔（1981 - 1985年、1986 - 1990年和1991 - 1995年）评估发病率。
在三个时间段（1981 - 1985年、1986 - 1990年和1991 - 1995年）观察到乳头状甲状腺癌（PTC）发病率上升，滤泡状甲状腺癌（FTC）发病率下降。三个时间段内，女性总体发病率从3.22到3.25以及3.73，男性从1.07到1.54以及1.69，随时间均无显著变化。DTC患者的预期寿命结局有显著改善。
碘预防措施确实会影响甲状腺癌组织学类型的分布，并导致乳头状癌与滤泡状癌的比例增加。我们的研究支持以下假设，即纠正碘缺乏的益处超过补充碘的风险。
