Inaguma Y, Shinohara H, Inagaki T, Kato K
Department of Biochemistry, Aichi Prefectural Colony, Japan.
J Neurol Sci. 1992 Jul;110(1-2):57-61. doi: 10.1016/0022-510x(92)90009-a.
By using a sensitive enzyme immunoassay system for rat parvalbumin, we determined parvalbumin contents in the 4 cerebrocortical regions (superior frontal gyrus of frontal lobe, parahippocampal gyrus of temporal lobe, superior parietal lobule of parietal lobe, and calcarine area of occipital lobe) of patients with Alzheimer's disease and age-matched controls. Among the 4 regions, concentrations of parvalbumin were the highest in calcarine area (68.6 +/- 6.7 ng/mg protein, rat parvalbumin equivalents, mean +/- SE) and the lowest in the parahippocampal gyrus (11.0 +/- 1.7 ng/mg protein) in the controls. A similar regional difference of the concentration was observed also in the patients with Alzheimer's disease. When compared with the controls, however, concentrations of parvalbumin in parahippocampal gyrus of patients with Alzheimer's disease (4.0 +/- 0.9 ng/mg protein) were significantly low (P less than 0.01), showing less than a half of the control values. In contrast, the concentrations in the 3 other regions showed little difference between Alzheimer's disease and the controls.
通过使用一种针对大鼠小白蛋白的灵敏酶免疫分析系统，我们测定了阿尔茨海默病患者和年龄匹配的对照组在4个脑皮质区域（额叶上额回、颞叶海马旁回、顶叶顶上小叶和枕叶距状区）中的小白蛋白含量。在对照组中，4个区域里，距状区的小白蛋白浓度最高（68.6±6.7纳克/毫克蛋白质，大鼠小白蛋白当量，平均值±标准误），海马旁回的最低（11.0±1.7纳克/毫克蛋白质）。在阿尔茨海默病患者中也观察到了类似的浓度区域差异。然而，与对照组相比，阿尔茨海默病患者海马旁回中的小白蛋白浓度（4.0±0.9纳克/毫克蛋白质）显著降低（P<0.01），不到对照值的一半。相比之下，其他3个区域的浓度在阿尔茨海默病患者和对照组之间几乎没有差异。
