阿苯达唑与甲硝唑治疗成人贾第虫病：一项开放性随机临床研究。
Albendazole versus metronidazole treatment of adult giardiasis: An open randomized clinical study.
作者信息
Karabay Oguz, Tamer Ali, Gunduz Huseyin, Kayas Derya, Arinc Huseyin, Celebi Harika
机构信息
Izzet Baysal Medical Faculty Infectious Disease Unit. Golkoy Kampusu/Bolu /Turkey.
出版信息
World J Gastroenterol. 2004 Apr 15;10(8):1215-7. doi: 10.3748/wjg.v10.i8.1215.
AIM
To investigate the efficacy and tolerability of albendazole and metranidazole treatment in giardiasis.
METHODS
The open comparative randomized trial was carried out prospectively from December 1999 to July 2001 in Duzce City of Turkey. The diagnosis was based on the presence of signs and symptoms compatible with giardiasis including a positive stool examination of giardia cysts or trophozoite. Metranidazole group consisted of 29 patients and was given metranidazole 500 mg, three times a day for 5 d and albendazole group was consisted of 28 patients and was given albendazole 400 mg/d for 5 d.
RESULTS
There were no significant differences in demographical and therapeutical effects and patient's compliance between both groups. But side effects were seen more in metranidazole group than in albendazole group.
CONCLUSION
Albendazole is as effective as metranidazole in adults' giardiasis. Albendazole has less side effect potentials than metranidazole in the treatment of giardiasis.
目的
探讨阿苯达唑和甲硝唑治疗贾第虫病的疗效及耐受性。
方法
1999年12月至2001年7月在土耳其杜兹市前瞻性地开展了开放性对照随机试验。诊断依据为存在与贾第虫病相符的体征和症状，包括粪便检查贾第虫囊肿或滋养体呈阳性。甲硝唑组有29例患者，给予甲硝唑500毫克，每日3次，共5天；阿苯达唑组有28例患者，给予阿苯达唑400毫克/天，共5天。
结果
两组在人口统计学、治疗效果及患者依从性方面无显著差异。但甲硝唑组的副作用比阿苯达唑组更多见。
结论
阿苯达唑在成人贾第虫病治疗中与甲硝唑疗效相当。在治疗贾第虫病方面，阿苯达唑的副作用可能性比甲硝唑更小。
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