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一名慢性肉芽肿病患者中与致命菌血症相关的菲氏弗朗西斯菌鉴定问题。

Problems in identification of Francisella philomiragia associated with fatal bacteremia in a patient with chronic granulomatous disease.

作者信息

Friis-Møller A, Lemming L E, Valerius N H, Bruun B

机构信息

Department of Clinical Microbiology, Hvidovre Hospital, Denmark.

出版信息

J Clin Microbiol. 2004 Apr;42(4):1840-2. doi: 10.1128/JCM.42.4.1840-1842.2004.

DOI:10.1128/JCM.42.4.1840-1842.2004
PMID:15071065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC387557/
Abstract

Francisella philomiragia is a rare gram-negative, halophilic coccobacillus with bizarre spherical forms on primary isolation. A case of F. philomiragia bacteremia in a 24-year-old patient with chronic granulomatous disease is reported. Identification of F. philomiragia was problematic with conventional tests but was done correctly and rapidly by kit 16S ribosomal DNA sequencing.

摘要

嗜肺弗朗西斯菌是一种罕见的革兰氏阴性嗜盐球杆菌，初次分离时呈奇异的球形。本文报道了一例24岁慢性肉芽肿病患者发生嗜肺弗朗西斯菌菌血症的病例。用传统检测方法鉴定嗜肺弗朗西斯菌存在问题，但通过试剂盒16S核糖体DNA测序能够正确且快速地完成鉴定。

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本文引用的文献

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Evaluation of PCR-based methods for discrimination of Francisella species and subspecies and development of a specific PCR that distinguishes the two major subspecies of Francisella tularensis.基于聚合酶链反应（PCR）的方法用于区分弗朗西斯菌属菌种和亚种的评估以及一种区分土拉弗朗西斯菌两个主要亚种的特异性PCR的开发。
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Chronic granulomatous disease.慢性肉芽肿病
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Recurrent Francisella philomiragia sepsis in chronic granulomatous disease.慢性肉芽肿病患者复发性海鱼弗朗西斯菌败血症
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Analysis of 16S ribosomal DNA sequences of Francisella strains and utilization for determination of the phylogeny of the genus and for identification of strains by PCR.弗朗西斯菌属菌株16S核糖体DNA序列分析及其在该属系统发育测定和通过聚合酶链反应鉴定菌株中的应用。
Int J Syst Bacteriol. 1994 Jan;44(1):38-46. doi: 10.1099/00207713-44-1-38.
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Chronic granulomatous disease: fatal septicemia caused by an unnamed gram-negative bacterium.慢性肉芽肿病：由一种未命名的革兰氏阴性细菌引起的致命败血症。
J Clin Microbiol. 1982 Nov;16(5):821-5. doi: 10.1128/jcm.16.5.821-825.1982.
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Yersinia philomiragia sp. n., a new member of the Pasteurella group of bacteria, naturally pathogenic for the muskrat (Ondatra zibethica).费氏耶尔森菌新种，巴斯德菌属细菌的一个新成员，对麝鼠（麝鼠属）具有天然致病性。
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Francisella philomiragia comb. nov. (formerly Yersinia philomiragia) and Francisella tularensis biogroup novicida (formerly Francisella novicida) associated with human disease.费氏弗朗西斯菌（新组合）（原称嗜肺耶尔森菌）和土拉弗朗西斯菌新凶手生物群（原称新凶手弗朗西斯菌）与人类疾病相关。
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Infection caused by Francisella philomiragia (formerly Yersinia philomiragia). A newly recognized human pathogen.由费氏弗朗西斯菌（以前称为嗜肺耶尔森菌）引起的感染。一种新发现的人类病原体。
Ann Intern Med. 1989 Jun 1;110(11):888-92. doi: 10.7326/0003-4819-110-11-888.