Rabinovsky Eric D
Michael E. DeBakey Department of Surgery, Division of Plastic Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Neurol Res. 2004 Mar;26(2):204-10. doi: 10.1179/016164104225013851.
The elements of peripheral nerve regeneration comprise a complex combination of nerve growth, muscle satellite cells proliferation and differentiation and vessel growth. There is also increasing evidence that growth factors may act at multiple levels in the regenerative response. One such factor affecting multiple cell processes is insulin-like growth factor (IGF-1). As a neurotrophic factor IGF-1 is known to promote nerve elongation and branching. As a myogenic factor, IGF-1 promotes satellite cell proliferation, differentiation and muscle hypertrophy. As an angiogenic factor, IGF-1 is known to promote angiogenesis in regenerating skeletal muscle by activating VEGF and VEGF receptors. Additionally, recent studies show that IGF-1 may also promote the activation of muscle stem cells during the regenerative process. This review will outline the pathways by which IGF-1 affects multiple layers of the regenerative response and how these pathways converge to promote the regeneration of nerves.
周围神经再生的要素包括神经生长、肌肉卫星细胞增殖与分化以及血管生长的复杂组合。越来越多的证据表明，生长因子可能在再生反应的多个层面发挥作用。胰岛素样生长因子（IGF-1）就是这样一种影响多个细胞过程的因子。作为一种神经营养因子，IGF-1已知可促进神经伸长和分支。作为一种生肌因子，IGF-1可促进卫星细胞增殖、分化和肌肉肥大。作为一种血管生成因子，IGF-1已知可通过激活VEGF和VEGF受体促进再生骨骼肌中的血管生成。此外，最近的研究表明，IGF-1在再生过程中也可能促进肌肉干细胞的激活。本综述将概述IGF-1影响再生反应多个层面的途径，以及这些途径如何共同促进神经再生。
