Kalus Peter, Buri Caroline, Slotboom Johannes, Gralla Jan, Remonda Luca, Dierks Thomas, Strik Werner K, Schroth Gerhard, Kiefer Claus
Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Freiburgstrasse, CH-3010 Bern, Switzerland.
Neuroreport. 2004 Apr 9;15(5):867-71. doi: 10.1097/00001756-200404090-00027.
Previous MRI-volumetric studies in schizophrenic psychoses have demonstrated more or less pronounced volume reductions of the hippocampus in patients. Correspondingly, neuropathological examinations on the brains of schizophrenics showed diverse structural changes of the hippocampus. Employing a high-resolution 3D-MPRAGE sequence, we found volume reductions in most hippocampal subregions of schizophrenic patients, which, however, did not reach significant levels. An analysis of co-registered diffusion tensor imaging (DTI) data revealed significant alterations of the inter-voxel coherences in single hippocampal subdivisions of these patients, supporting the assumption of characteristic microstructural tissue changes relevant for the pathogenesis of schizophrenic psychoses. Our results argue for the usage of additional MRI modalities like DTI in order to detect subtle regional alterations of hippocampal structure in schizophrenics.
先前针对精神分裂症性精神病的MRI容积研究表明，患者的海马体或多或少存在明显的体积减小。相应地，对精神分裂症患者大脑的神经病理学检查显示海马体存在多种结构变化。采用高分辨率3D-MPRAGE序列，我们发现精神分裂症患者的大多数海马亚区体积减小，然而，这些减小并未达到显著水平。对共同配准的扩散张量成像（DTI）数据的分析显示，这些患者单个海马亚区的体素间相干性存在显著改变，支持了与精神分裂症性精神病发病机制相关的特征性微观结构组织变化的假设。我们的结果支持使用像DTI这样的额外MRI模态，以检测精神分裂症患者海马体结构的细微区域变化。
