DeRossi Scott S, Laudenbach Joel
Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104, USA.
Cutis. 2004 Mar;73(3):191-3.
Cidofovir, a purine nucleotide analog of cytosine, has showed significant promise against a number of DNA viruses. In 1997, the US Food and Drug Administration approved the use of cidofovir intravenously in the treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Recent studies and reports suggest that a topical form of cidofovir may be useful for treating viral cutaneous lesions recalcitrant to traditional treatments. We report the case of a 36-year-old man with human immunodeficiency virus (HIV) and recalcitrant human papillomavirus (HPV) lesions on the gingiva that were successfully treated with cidofovir gel 1%.
西多福韦是一种胞嘧啶的嘌呤核苷酸类似物，已显示出对多种DNA病毒具有显著疗效。1997年，美国食品药品监督管理局批准静脉注射西多福韦用于治疗获得性免疫缺陷综合征患者的巨细胞病毒性视网膜炎。最近的研究和报告表明，局部使用西多福韦可能有助于治疗对传统治疗有抵抗性的病毒性皮肤损伤。我们报告了一例36岁男性患者的病例，该患者感染了人类免疫缺陷病毒（HIV），牙龈上有顽固性人乳头瘤病毒（HPV）损伤，使用1%的西多福韦凝胶成功治愈。
