Myint Michael, Bashiri Houman, Harrington Robert D, Marra Christina M
Department of Medicine (Infectious Diseases), University of Washington School of Medicine, Seattle, Washington, USA.
Sex Transm Dis. 2004 Mar;31(3):196-9. doi: 10.1097/01.olq.0000114941.37942.4c.
It is difficult to distinguish between relapse and reinfection in patients who develop a second episode of syphilis after treatment.
The goal of this study was to use molecular methods to distinguish between relapse and reinfection in a patient with recurrent secondary syphilis.
Treponema pallidum tprK sequences were amplified from cerebrospinal fluid (CSF), skin, and blood from the initial presentation and from blood from the second presentation. Neighbor-joining clustering analysis was performed for deduced tprK sequences from the case patient and for sequences derived from blood and CSF of a different patient with secondary syphilis.
The case patient's tprK sequences from both episodes of syphilis clustered together with a high degree of similarity.
Our patient likely relapsed despite treatment.
梅毒治疗后出现二期梅毒发作的患者，很难区分是复发还是再感染。
本研究的目的是使用分子方法区分复发性二期梅毒患者的复发和再感染。
从初次就诊时的脑脊液（CSF）、皮肤和血液以及第二次就诊时的血液中扩增梅毒螺旋体tprK序列。对该病例患者推导的tprK序列以及来自另一名二期梅毒患者的血液和脑脊液的序列进行邻接法聚类分析。
该病例患者梅毒两次发作的tprK序列以高度相似性聚集在一起。
尽管接受了治疗，我们的患者可能复发了。
