Sackesen Cansin, Sekerel Bulent E, Orhan Fazil, Kocabas Can Naci, Tuncer Ayfer, Adalioglu Gonul
Hacettepe University Medical Faculty, Pediatric Allergy and Asthma Unit, Ihsan Doğramaci Children's Hospital, Sihhiye, 06100 Ankara, Turkey.
Pediatr Dermatol. 2004 Mar-Apr;21(2):102-8. doi: 10.1111/j.0736-8046.2004.21202.x.
Urticaria is a common disease in children. In contrast to the ease of its diagnosis, etiologic factors are often difficult to determine. In order to study whether differences exist among various forms of urticaria in childhood and whether the patterns of different types of urticaria differ between adults and children, we extensively studied the possible causes of urticaria in children. Fifty-four children (23 girls and 31 boys; ages 1-19 years) with various forms of urticaria were included in the study. In all cases, questions about food allergies, food additive intolerance, drug intake, signs of infection, causes of physical urticaria, insect bites, and personal and family history of atopy were asked. Clinical characteristics of the disease, such as duration, recurrence, and associated angioedema and symptoms of anaphylaxis were also investigated. Detailed laboratory tests, including serologic, autoimmune, and allergic analyses, were conducted to reveal the probable etiologies of urticaria. Of the study patients, 68.5% and 31.5% were diagnosed as having acute and chronic urticaria, respectively. The patient group with chronic urticaria was older and included more boys than the acute group. In the acute urticaria group, infection was the most frequently documented cause (48.6%), followed by drugs (5.4%), and food allergies (2.7%), whereas in chronic urticaria, physical factors were the leading cause (52.94%). The most frequently documented infection was urinary tract infection, followed by serologically determined infections of Chlamydia pneumoniae and Helicobacter pylori. In this study we found indications that infections were frequently associated with urticaria, which suggests that urticaria management should include a survey of certain infectious agents in addition to a detailed history.
荨麻疹是儿童常见疾病。与诊断的容易程度形成对比的是，病因往往难以确定。为了研究儿童不同类型荨麻疹之间是否存在差异，以及成人和儿童不同类型荨麻疹的模式是否不同，我们广泛研究了儿童荨麻疹的可能病因。54名患有各种类型荨麻疹的儿童（23名女孩和31名男孩；年龄1至19岁）被纳入研究。在所有病例中，询问了有关食物过敏、食物添加剂不耐受、药物摄入、感染迹象、物理性荨麻疹病因、昆虫叮咬以及个人和家族特应性病史的问题。还调查了该疾病的临床特征，如病程、复发情况以及相关的血管性水肿和过敏反应症状。进行了详细的实验室检查，包括血清学、自身免疫和过敏分析，以揭示荨麻疹的可能病因。在研究患者中，分别有68.5%和31.5%被诊断为患有急性和慢性荨麻疹。慢性荨麻疹患者组年龄较大，男孩比急性组更多。在急性荨麻疹组中，感染是最常见的病因（48.6%），其次是药物（5.4%）和食物过敏（2.7%），而在慢性荨麻疹中，物理因素是主要病因（52.94%）。最常记录的感染是尿路感染，其次是血清学确定的肺炎衣原体和幽门螺杆菌感染。在本研究中，我们发现有迹象表明感染常与荨麻疹相关，这表明荨麻疹的治疗除了详细的病史外，还应包括对某些感染因子的调查。
