Robertson M D, Henderson R A, Vist G E, Rumsey R D E
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Int J Obes Relat Metab Disord. 2004 Jun;28(6):727-33. doi: 10.1038/sj.ijo.0802637.
Ghrelin, a 28 amino-acid peptide secreted primarily from the stomach has been identified as the endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is suppressed in the postprandial state and has been linked to both type II diabetes and obesity.
To investigate the effects of a period of overfeeding with high-fat dietary supplements on plasma ghrelin levels in nonobese men.
Six healthy males (21-34 y; BMI 21-24 kg/m(2)) underwent the dietary intervention after completing diet and exercise diaries for 7 days. For 3 further weeks subjects followed their own diet diary supplemented with 125 ml single cream and 50 g roasted peanuts (88 g fat, 15 g Protein, 8 g carbohydrate) every day. Oral fat tolerance tests (OFTT) were undertaken at baseline, 7, 14 and 21 days of fat supplementation. The diet was increased in energy by 3.9 MJ/day and from a mean of 29-45% energy intake from fat with a small weight gain noted each week (P=0.009).
Ghrelin concentrations were significantly reduced during the baseline OFTT. The postprandial ghrelin response (AUC) was significantly reduced following 2 weeks of dietary supplementation (P=0.005) increasing the suppression of plasma ghrelin by 18% despite only a 3% increase in body weight. Plasma triacylglycerol (P=0.009) and leptin (P=0.035) concentrations were also elevated and postprandial pancreatic polypeptide levels decreased (P=0.038) following dietary-supplementation.
These results suggest that the metabolic profile associated with obesity, including a reduction in plasma ghrelin levels, may be related to recent dietary energy intake and precedes the development of significant adiposity.
胃饥饿素是一种主要由胃分泌的含28个氨基酸的肽，已被确定为生长激素促分泌素受体的内源性配体。胃饥饿素在餐后状态下受到抑制，并且与II型糖尿病和肥胖症都有关联。
研究一段时间高脂饮食补充过量喂养对非肥胖男性血浆胃饥饿素水平的影响。
6名健康男性（21 - 34岁；体重指数21 - 24kg/m²）在完成7天的饮食和运动日记后接受饮食干预。在接下来的3周里，受试者遵循自己的饮食日记，每天额外补充125毫升单奶油和50克烤花生（88克脂肪、15克蛋白质、8克碳水化合物）。在补充脂肪的基线、第7天、第14天和第21天进行口服脂肪耐量试验（OFTT）。饮食能量每天增加3.9兆焦耳，脂肪能量摄入量从平均29%增加到45%，每周体重有少量增加（P = 0.009）。
在基线OFTT期间，胃饥饿素浓度显著降低。饮食补充2周后，餐后胃饥饿素反应（AUC）显著降低（P = 0.005），尽管体重仅增加3%，但血浆胃饥饿素的抑制增加了18%。饮食补充后，血浆三酰甘油（P = 0.009）和瘦素（P = 0.035）浓度也升高，餐后胰多肽水平降低（P = 0.038）。
这些结果表明，与肥胖相关的代谢特征，包括血浆胃饥饿素水平降低，可能与近期饮食能量摄入有关，且在显著肥胖发生之前就已出现。
