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[胸腺素对神经致敏雌性大鼠后代大脑蛋白质合成及条件反射活动的影响]

[Effect of thymalin on protein synthesis in the brain and conditioned-reflex activity of the progeny of neurosensitized female rats].

作者信息

Trekova N A

出版信息

Biull Eksp Biol Med. 1987 Nov;104(11):535-7.

PMID:3676482
Abstract

Thymalin administration to two-week-old offspring of neurosensitized female rats prevented the development of protein synthesis disturbances in the central nervous system and the retention of conditioned reflex of passive avoidance. Thymalin injection to the offspring of intact female rats improved conditioned reflex retention and did not affect brain protein synthesis. A possible mechanism of thymalin effect in conditions of congenital neuroimmunopathology is discussed.

摘要

给神经致敏雌性大鼠两周大的后代注射胸腺素,可预防中枢神经系统蛋白质合成紊乱的发展以及被动回避条件反射的保留。给未受影响雌性大鼠的后代注射胸腺素可改善条件反射的保留,且不影响脑蛋白质合成。本文讨论了胸腺素在先天性神经免疫病理学条件下发挥作用的可能机制。

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