Tohgi H, Abe T, Nakanishi M, Hamato F, Sasaki K, Takahashi S
Department of Neurology, Iwate Medical University, Morioka, Japan.
Neurosci Lett. 1994 Jun 6;174(1):73-6. doi: 10.1016/0304-3940(94)90122-8.
We determined the concentrations of alpha-tocopherol (alpha-TOH) and alpha-tocopherol quinone(alpha-TQ), an oxidized derivative of alpha-TOH, in cerebrospinal fluid from patients with Alzheimer type dementia (ATD) and those with vascular dementia of the Binswanger type (VDBT). Compared with results for the controls, the VDBT patients had unaltered concentrations of alpha-TOH, but a statistically significant, 3.6-fold increase of alpha-TQ (P < 0.01) which was significantly correlated with decreases in the Mini-Mental State Examination scores (P < 0.05). In contrast, ATD patients had significantly decreased concentrations of alpha-TOH (P < 0.01), but had unaltered concentrations of alpha-TQ. These results suggest that there is greater oxidation of alpha-TOH to alpha-TQ in VDBT brain, but are inconclusive about the occurrence of peroxidation in ATD brains.
我们测定了阿尔茨海默型痴呆（ATD）患者和宾斯旺格型血管性痴呆（VDBT）患者脑脊液中α-生育酚（α-TOH）及其氧化衍生物α-生育酚醌（α-TQ）的浓度。与对照组结果相比，VDBT患者的α-TOH浓度未改变，但α-TQ浓度有统计学意义地增加了3.6倍（P < 0.01），且与简易精神状态检查表评分的降低显著相关（P < 0.05）。相比之下，ATD患者的α-TOH浓度显著降低（P < 0.01），但α-TQ浓度未改变。这些结果表明，VDBT脑内α-TOH向α-TQ的氧化程度更高，但关于ATD脑内是否发生过氧化反应尚无定论。
