Haydar Ali A, Covic Adrian, Colhoun Helen, Rubens Michael, Goldsmith David J A
Renal and Transplantation Unit, Guy's Hospital, London, UK.
Kidney Int. 2004 May;65(5):1790-4. doi: 10.1111/j.1523-1755.2004.00581.x.
Patients with end-stage renal disease (ESRD) are at increased risk of cardiovascular mortality and morbidity. Many complications arise in ESRD patients as a result of the twin arterial pathologies of atherosclerosis and arteriosclerosis. Part of this latter process is calcification of the arterial media, which is thought significantly to increase vascular stiffness. The aim of our study was to explore the relationship between measures of arterial stiffness-pulse wave velocity (PWV)-and the extent of calcification in the coronary arteries (CAC).
Over a period of 2 years 82 patients from our renal unit were invited to participate in our study. Sixty-two patients agreed to undergo electron beam computerized tomography (EBCT), and in 55 (38 males and 17 females), PWV measurements were made. EBCT and PWV measurements were done according to previously described protocols.
The mean age of the 55 patients was 56.4 years. The mean duration of dialysis was 65.4 months, and the mean CAC score was 2551. The mean PWV was 9.13 m/s. PWV strongly correlated with total CAC even after correction for age, dialysis duration, and time averaged C-reactive protein (CRP) (P= 0.0001). CAC scores were significantly different when compared according to PWV tertiles (P= 0.0001).
We have demonstrated that PWV is strongly related to the degree of EBCT-derived coronary artery calcium score in chronic kidney disease patients.
终末期肾病（ESRD）患者心血管疾病死亡率和发病率增加。由于动脉粥样硬化和动脉硬化这两种动脉病变，ESRD患者会出现许多并发症。后一过程的一部分是动脉中层钙化，这被认为会显著增加血管硬度。我们研究的目的是探讨动脉僵硬度指标——脉搏波速度（PWV）——与冠状动脉钙化（CAC）程度之间的关系。
在2年时间里，邀请了我们肾科的82名患者参与研究。62名患者同意接受电子束计算机断层扫描（EBCT），其中55名（38名男性和17名女性）进行了PWV测量。EBCT和PWV测量均按照先前描述的方案进行。
55名患者的平均年龄为56.4岁。平均透析时间为65.4个月，平均CAC评分为2551。平均PWV为9.13米/秒。即使在校正年龄、透析时间和时间平均C反应蛋白（CRP）后，PWV与总CAC仍密切相关（P = 0.0001）。根据PWV三分位数进行比较时，CAC评分有显著差异（P = 0.0001）。
我们已经证明，在慢性肾病患者中，PWV与EBCT得出的冠状动脉钙化评分程度密切相关。
