Garden Adam S, Morrison William H, Rosenthal David I, Chao K S Clifford, Ang K Kian
Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Semin Radiat Oncol. 2004 Apr;14(2):103-9. doi: 10.1053/j.semradonc.2003.12.004.
The use of intensity-modulated radiation (IMRT) for the treatment of head and neck cancers is less than a decade old, and long-term clinical results both with regards to tumor outcome and late radiation toxicity are still lacking. Despite this limitation, the use of IMRT is gaining popularity. Preliminary clinical experiences have been encouraging, suggesting that the 2 goals of IMRT for treatment of head and neck cancer can be achieved. These goals are improved tumor coverage reflected in high rates of disease control and a decrease of toxicity. The availability of IMRT has forced head and neck radiation oncologists to both rethink old practices as well as potentially introduce new therapeutic paradigms. This review will focus on how IMRT is being implemented into the treatment of head and neck cancer, specifically with regards to target definition and dosing issues.
调强放射治疗（IMRT）用于治疗头颈癌的时间尚不足十年，目前仍缺乏关于肿瘤治疗结果和晚期放射毒性的长期临床数据。尽管存在这一局限性，IMRT的应用却日益广泛。初步临床经验令人鼓舞，表明IMRT用于治疗头颈癌的两个目标能够实现。这两个目标分别是：通过高疾病控制率反映出的肿瘤覆盖改善，以及毒性降低。IMRT的出现促使头颈放疗肿瘤学家重新审视以往的做法，并有可能引入新的治疗模式。本综述将重点关注IMRT如何应用于头颈癌治疗，特别是在靶区定义和剂量问题方面。
