Rao Srinivas K, Meenakshi Swaminathan, Srinivasan Bhaskar, Baluswamy Sukumar
Medical & Vision Research Foundations, 18, College Road, Chennai 600 006, Tamil Nadu, India.
Cornea. 2004 May;23(4):356-9. doi: 10.1097/00003226-200405000-00008.
To prospectively evaluate the occurrence of perilimbal conjunctival pigmentation in patients with vernal conjunctivitis and normal controls; to document the location, extent, density, and color of such pigmentation; and to correlate these changes with disease severity.
Prospective, noninterventional case-control study. Demographic data, disease symptoms and duration, clinical signs of disease severity and extent, and characteristics of the perilimbal pigmentation were recorded.
Twenty-five patients with vernal conjunctivitis and 30 controls were studied. The mean age of the patients (21 M, 4 F) and controls (18 M, 12 F) was 7.5 +/- 3.7 years and 10.3 +/- 3.1 years, respectively. Perilimbal pigmentation was seen in all patients with vernal conjunctivitis and in none of the controls. The palpebral conjunctival changes and patient symptoms correlated with the severity of the disease in patients with vernal conjunctivitis. However, the extent of perilimbal pigmentation did not correlate with the symptoms and signs of vernal conjunctivitis or the density of palisadal pigment.
Perilimbal bulbar conjunctival pigmentation appears to be a consistent finding in patients with vernal conjunctivitis that is both specific and sensitive. It is also present in eyes with inactive disease and hence is a useful clinical sign that aids diagnosis in patients with mild or quiescent disease. Further studies are required to establish the histopathologic correlation of this finding and its etiopathogenesis. It is also important to establish whether this finding occurs with the same frequency in eyes of whites, as this study was performed in a cohort of Asian patients who have greater limbal pigmentation and a higher incidence of limbal changes in vernal conjunctivitis.
前瞻性评估春季结膜炎患者及正常对照者角膜缘结膜色素沉着的发生情况；记录此类色素沉着的位置、范围、密度及颜色；并将这些变化与疾病严重程度相关联。
前瞻性、非干预性病例对照研究。记录人口统计学数据、疾病症状及病程、疾病严重程度和范围的临床体征以及角膜缘色素沉着的特征。
研究了25例春季结膜炎患者和30例对照者。患者（21例男性，4例女性）和对照者（18例男性，12例女性）的平均年龄分别为7.5±3.7岁和10.3±3.1岁。所有春季结膜炎患者均出现角膜缘色素沉着，而对照者均未出现。睑结膜变化及患者症状与春季结膜炎患者的疾病严重程度相关。然而，角膜缘色素沉着的范围与春季结膜炎的症状和体征或睑裂区色素密度无关。
角膜缘球结膜色素沉着似乎是春季结膜炎患者的一个一致发现，具有特异性和敏感性。它也存在于非活动性疾病的眼中，因此是一个有用的临床体征，有助于诊断轻度或静止期疾病的患者。需要进一步研究来确定这一发现的组织病理学相关性及其发病机制。同样重要的是要确定在白人眼中这一发现的发生频率是否相同，因为本研究是在一组亚洲结膜炎患者角膜色素沉着较多且角膜缘变化发生率较高的亚洲患者队列中进行的。
