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伴有广泛表皮凋亡的线状色素沉着:线状扁平苔藓色素沉着的一种变异型?

Linear hyperpigmentation with extensive epidermal apoptosis: a variant of linear lichen planus pigmentosus?

作者信息

Akagi Atsushi, Ohnishi Yoshihiro, Tajima Shingo, Ishibashi Akira

机构信息

Department of Dermatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.

出版信息

J Am Acad Dermatol. 2004 May;50(5 Suppl):S78-80. doi: 10.1016/j.jaad.2003.11.067.

Abstract

We report 3 female patients who rapidly developed pigmented patches in a linear arrangement. Histologically there was minimum epidermal basal cell damage and bandlike lymphocyte infiltration in the dermis, but focal massive apoptotic materials positively stained with antikeratin antibody were prominently seen in the papillary and subpapillary dermis. We considered these cases as a variant of linear lichen planus pigmentosus with unique histologic change of severe epidermal apoptosis. These histologic features may represent a severe apoptotic change in the end stage of lichenoid tissue reaction.

摘要

我们报告了3例女性患者,她们迅速出现呈线状排列的色素沉着斑。组织学检查显示,表皮基底细胞损伤轻微,真皮有带状淋巴细胞浸润,但在乳头层和乳头下层真皮中可见局灶性大量抗角蛋白抗体阳性的凋亡物质。我们认为这些病例是色素性线状扁平苔藓的一种变体,具有严重表皮凋亡的独特组织学变化。这些组织学特征可能代表苔藓样组织反应终末期的严重凋亡变化。

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