Smokovitis A, Kokolis N, Tsandarliotou M
Department of Physiology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.
Thromb Res. 1993 Mar 1;69(5):425-33. doi: 10.1016/0049-3848(93)90231-c.
Plasminogen activator activity (PAA), t-PA antigen level, plasminogen activator inhibition (PAI) and plasmin inhibition (PI) showed a circadian variation in rat aorta, heart, brain, and lungs of both sexes, but in a different way depending on the organ and the fibrinolytic parameter studied and the sex as well. In general, the lowest values of PAA and t-PA antigen were found in the early morning and the highest values in late afternoon, while PAI or PI showed the opposite pattern (with the exception of lungs). In kidneys and liver the fibrinolytic parameters studied showed no circadian variation. Sex-related differences, mostly quantitative, were noted in aorta, heart, brain and kidneys, with lower PAA and t-PA antigen and higher PAI or PI in the male than in the female.
纤溶酶原激活物活性（PAA）、组织型纤溶酶原激活物（t-PA）抗原水平、纤溶酶原激活物抑制物（PAI）和纤溶酶抑制物（PI）在雌雄大鼠的主动脉、心脏、脑和肺中均呈现昼夜变化，但根据所研究的器官、纤溶参数以及性别不同，变化方式也有所不同。一般来说，PAA和t-PA抗原的最低值出现在清晨，最高值出现在傍晚，而PAI或PI则呈现相反的模式（肺除外）。在肾脏和肝脏中，所研究的纤溶参数未显示出昼夜变化。在主动脉、心脏、脑和肾脏中发现了与性别相关的差异，主要是数量上的差异，雄性的PAA和t-PA抗原较低，PAI或PI较高，而雌性则相反。
