Godfrey Simon
Institute of Pulmonology, Hadassah University Hospital, Jerusalem, Israel.
Pediatr Pulmonol. 2004 Jun;37(6):476-84. doi: 10.1002/ppul.20020.
Pulmonary hemorrhage and hemoptysis are uncommon in childhood, and the frequency with which they are encountered by the pediatric pulmonologist depends largely on the special interests of the center to which the child is referred. In those centers caring for children with cystic fibrosis or congenital heart disease, these will be by far the most common causes of hemoptysis. Other causes of hemoptysis are far less common, such as bleeding from localized lesions in the upper airway or tracheobronchial tree. Even less common is bleeding into the lungs as part of a systemic disease, usually with renal involvement (pulmonary-renal syndromes), such as systemic lupus erythematosis or Goodpasture's syndrome. Bleeding into the lungs in children with a bleeding diathesis probably only occurs in immunosuppressed children after transplantation. When no other cause is found for pulmonary hemorrhage, the presumed diagnosis is idiopathic pulmonary hemosiderosis. This review discusses the various causes of hemoptysis and pulmonary hemorrhage, and the appropriate investigations to aid in determining the correct diagnosis. The management and prognosis of idiopathic pulmonary hemosiderosis, based on cumulative experience from published reports, are considered in more detail.
肺出血和咯血在儿童时期并不常见,儿科肺科医生遇到这些情况的频率在很大程度上取决于患儿所转诊中心的特殊兴趣。在那些照料患有囊性纤维化或先天性心脏病儿童的中心,这些疾病将是迄今为止咯血最常见的原因。咯血的其他原因则要少见得多,例如上呼吸道或气管支气管树局部病变出血。作为系统性疾病一部分的肺内出血更为罕见,通常伴有肾脏受累(肺-肾综合征),如系统性红斑狼疮或古德帕斯丘综合征。有出血倾向的儿童发生肺内出血可能仅见于移植后免疫抑制的儿童。当未发现肺出血的其他原因时,推测诊断为特发性肺含铁血黄素沉着症。本综述讨论了咯血和肺出血的各种原因,以及有助于确定正确诊断的适当检查。基于已发表报告的累积经验,更详细地考虑了特发性肺含铁血黄素沉着症的管理和预后。