Phares Dana A, Halverstadt Amy A, Shuldiner Alan R, Ferrell Robert E, Douglass Larry W, Ryan Alice S, Goldberg Andrew P, Hagberg James M
Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
Obes Res. 2004 May;12(5):807-15. doi: 10.1038/oby.2004.97.
To examine the contribution of adrenergic receptor (ADR) gene polymorphisms and their gene-gene interactions to the variability of exercise training-induced body fat response.
This was an intervention study that used a volunteer sample of 70 healthy, sedentary men (n = 29) and postmenopausal women (n = 41) 50 to 75 years of age, with a BMI < or = 37 kg/m2, from the Washington, DC, metropolitan area. Participants completed 6 weeks of dietary stabilization (American Heart Association diet) before 24 weeks of supervised aerobic exercise training. Diet was maintained throughout the intervention. Change in percent total body fat, percent trunk fat, and fat mass by DXA in ADR genotype groups (Glu12/Glu9 alpha2b-ADR, Trp64Arg beta3-ADR, and Gln27Glu beta2-ADR) at baseline and after 24 weeks of aerobic exercise training was measured.
In multivariate analysis (covariates: age, gender, and baseline value of phenotype), best fit models for percent total body and trunk fat response to exercise training retained main effects of all three ADR gene loci and the effects of each gene-gene interaction (p = 0.009 and 0.003, respectively). Similarly, there was a trend for the fat mass response model (p = 0.03). The combined genetic factors explained 17.5% of the overall model variability for percent total body fat, 22% for percent trunk fat, and 10% for fat mass.
The body fat response to exercise training in older adults is associated with the combined effects of the Glu12/Glu9 alpha2b-, Trp64Arg beta3-, and Gln27Glu beta2-ADR gene variants and their gene-gene interactions.
研究肾上腺素能受体（ADR）基因多态性及其基因-基因相互作用对运动训练诱导的体脂反应变异性的影响。
这是一项干预性研究，对来自华盛顿特区都会区的70名年龄在50至75岁、BMI≤37 kg/m²的健康久坐男性（n = 29）和绝经后女性（n = 41）志愿者样本进行了研究。参与者在接受24周的有监督有氧运动训练前，先进行了6周的饮食稳定期（采用美国心脏协会饮食）。在整个干预过程中饮食保持不变。测量了ADR基因型组（Glu12/Glu9 α2b-ADR、Trp64Arg β3-ADR和Gln27Glu β2-ADR）在基线时以及有氧运动训练24周后的全身脂肪百分比、躯干脂肪百分比和通过双能X线吸收法测量的脂肪量的变化。
在多变量分析中（协变量：年龄、性别和表型的基线值），全身和躯干脂肪百分比对运动训练反应的最佳拟合模型保留了所有三个ADR基因位点的主效应以及每个基因-基因相互作用的效应（分别为p = 0.009和0.003）。同样，脂肪量反应模型也有这种趋势（p = 0.03）。综合遗传因素解释了全身脂肪百分比总体模型变异性的17.5%、躯干脂肪百分比的22%和脂肪量的10%。
老年人对运动训练的体脂反应与Glu12/Glu9 α2b-、Trp64Arg β3-和Gln27Glu β2-ADR基因变异及其基因-基因相互作用的综合效应有关。
