Roza Carolina, Puel Jean-Luc, Kress Michaela, Baron Anne, Diochot Sylvie, Lazdunski Michel, Waldmann Rainer
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.
J Physiol. 2004 Jul 15;558(Pt 2):659-69. doi: 10.1113/jphysiol.2004.066001. Epub 2004 May 28.
Mechanosensitive cation channels are thought to be crucial for different aspects of mechanoperception, such as hearing and touch sensation. In the nematode C. elegans, the degenerins MEC-4 and MEC-10 are involved in mechanosensation and were proposed to form mechanosensitive cation channels. Mammalian degenerin homologues, the H(+)-gated ASIC channels, are expressed in sensory neurones and are therefore interesting candidates for mammalian mechanosensors. We investigated the effect of an ASIC2 gene knockout in mice on hearing and on cutaneous mechanosensation and visceral mechanonociception. However, our data do not support a role of ASIC2 in those facets of mechanoperception.
机械敏感阳离子通道被认为在机械感知的不同方面起着关键作用,比如听觉和触觉。在秀丽隐杆线虫中,退化素MEC - 4和MEC - 10参与机械感觉,并被认为可形成机械敏感阳离子通道。哺乳动物的退化素同源物,即H⁺门控的酸敏感离子通道(ASIC),在感觉神经元中表达,因此是哺乳动物机械传感器的有趣候选者。我们研究了小鼠中ASIC2基因敲除对听觉、皮肤机械感觉和内脏机械性伤害感受的影响。然而,我们的数据并不支持ASIC2在这些机械感知方面发挥作用。