Lin C C, Chen S Y, Lin J M, Chiu H F
School of Pharmacy, Kaohsiung Medical College, R.O.C.
Am J Chin Med. 1992;20(2):135-46. doi: 10.1142/S0192415X9200014X.
The bark, xylem of stem, and root of (1) Bombax malabarica DC. and (2) Ceiba pentandra GAERTN. are marked as "Mu-mien" in Taiwan. In order to clarify the pharmacological effects of these three parts, anti-inflammatory and liver protective effect were evaluated with carrageenan-induced paw edema and CCl4-induced hepatotoxicity in rats. The statistical analysis (ANOVA) shows that all of the treatment used exhibited significant anti-inflammatory activity against carrageenan-induced edema. Furthermore, the administration of root and xylem of stem of B. malabarica showed the activity even better than indomethacin group did. However, only three used parts of B. malabarica significantly alleviated liver injury induced by CCl4. Meanwhile, the histological changes in rat hepatic tissues such as fatty change, ballooning degeneration, cell necrosis, lymphocytes and Kupffer cells were also observed.
（1）木棉（Bombax malabarica DC.）和（2）吉贝（Ceiba pentandra GAERTN.）的树皮、茎木质部及根在台湾被标记为“木棉”。为阐明这三个部位的药理作用，通过角叉菜胶诱导大鼠足肿胀及四氯化碳诱导肝毒性，对其抗炎和肝保护作用进行了评估。统计分析（方差分析）表明，所有用药处理均对角叉菜胶诱导的水肿表现出显著抗炎活性。此外，木棉根和茎木质部给药的活性甚至优于吲哚美辛组。然而，仅木棉的三个用药部位显著减轻了四氯化碳诱导的肝损伤。同时，还观察到大鼠肝组织的组织学变化，如脂肪变性、气球样变性、细胞坏死、淋巴细胞及库普弗细胞等。
