Lin C C, Lin J M, Chiu H F
School of Pharmacy, Kaohsiung Medical College.
Am J Chin Med. 1992;20(1):37-50. doi: 10.1142/S0192415X92000059.
Five species of crude drugs are used as "Thang-kau-tin" on Taiwan market: (1) the stem of Mallotus repandus (Willd.) Muell.-Arg, (2) the stem and root of M. repandus (Willd.) Muell.-Arg, (3) the stem of Bauhinia championii Benth, (4) the stem with hooks of Uncaria hirsuta Haviland and (5) the stem with hooks of U. rhynchophylla Miquel. To clarify the effect of these crude drugs as anti-inflammatory and liver-protective agents, studies were conducted on water extracts of these five crude drugs. The statistical analysis (ANOVA) indicated that the stem of M. repandus showed the best anti-inflammatory activity against the paw edema induced by carrageenan. Nevertheless, the acute increase of GOT and GPT levels caused by CCl4 were markedly decreased by the treatment of M. repandus (stem), B. championii and U. hirsuta as a recipe group. The pathological changes around the central vein including fatty change, ballooning degeneration, cell necrosis, the increase in lymphocytes and Kupffer cells were improved by the treatment with the group of crude drugs as mentioned above.
台湾市场上有五种中药材被用作“唐金藤”：(1) 白背叶的茎，(2) 白背叶的茎和根，(3) 龙须藤的茎，(4) 毛钩藤带钩的茎，(5) 钩藤带钩的茎。为阐明这些中药材作为抗炎和保肝药物的作用，对这五种中药材的水提取物进行了研究。统计分析（方差分析）表明，白背叶的茎对角叉菜胶诱导的爪肿胀表现出最佳的抗炎活性。然而，作为一个配方组，用白背叶（茎）、龙须藤和毛钩藤处理可显著降低四氯化碳引起的谷草转氨酶（GOT）和谷丙转氨酶（GPT）水平的急性升高。用上述中药材组进行治疗可改善中央静脉周围的病理变化，包括脂肪变性、气球样变性、细胞坏死、淋巴细胞和库普弗细胞增多。
