Liu Jing, Mushegian Arcady
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
J Bacteriol. 2004 Jul;186(13):4369-75. doi: 10.1128/JB.186.13.4369-4375.2004.
Most of the known prohead maturation proteases in double-stranded-DNA bacteriophages are shown, by computational methods, to fall into two evolutionarily independent clans of serine proteases, herpesvirus assemblin-like and ClpP-like. Phylogenetic analysis suggests that these two types of phage prohead protease genes displaced each other multiple times while preserving their exact location within the late operons of the phage genomes.
通过计算方法表明,双链DNA噬菌体中大多数已知的前头部成熟蛋白酶属于丝氨酸蛋白酶的两个进化上独立的家族,即疱疹病毒装配素样家族和ClpP样家族。系统发育分析表明,这两种类型的噬菌体前头部蛋白酶基因在噬菌体基因组晚期操纵子内保持其确切位置的同时多次相互取代。