尽管将拉米夫定治疗作为高效抗逆转录病毒治疗（HAART）的一部分，但在合并感染人类免疫缺陷病毒（HIV）和乙型肝炎病毒（HBV）的患者中仍出现免疫重建性肝炎。
Immune reconstitution hepatitis in HIV and hepatitis B coinfection, despite lamivudine therapy as part of HAART.
作者信息
Drake Anne, Mijch Anne, Sasadeusz Joe
机构信息
The Alfred Hospital, Melbourne, Australia.
出版信息
Clin Infect Dis. 2004 Jul 1;39(1):129-32. doi: 10.1086/421386. Epub 2004 Jun 1.
DOI:10.1086/421386
PMID:15206064
Abstract
Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection occurs commonly. The introduction of antiretroviral therapy can result in immune reconstitution hepatitis. We describe 2 coinfected patients who developed clinical flares of HBV disease, despite the inclusion of lamivudine, a drug with anti-HBV activity, in their HAART regimens. Potential strategies to manage individuals with HBV/HIV coinfection are discussed.
摘要
乙型肝炎病毒（HBV）与人类免疫缺陷病毒（HIV）合并感染很常见。抗逆转录病毒疗法的应用可能导致免疫重建性肝炎。我们描述了2例合并感染患者，尽管其高效抗逆转录病毒治疗（HAART）方案中包含具有抗HBV活性的药物拉米夫定，但仍出现了HBV疾病的临床发作。本文讨论了管理HBV/HIV合并感染个体的潜在策略。
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