Goh Stella, Reacher Mark, Casemore David P, Verlander Neville Q, Chalmers Rachel, Knowles Margaret, Williams Joy, Osborn Keith, Richards Sarah
Carlisle and District Primary Care Trust, Rosehill, Carlisle, United Kingdom.
Emerg Infect Dis. 2004 Jun;10(6):1007-15. doi: 10.3201/10.3201/eid1006.030325.
Risk factors for sporadic cryptosporidiosis were determined in 152 patients and 466 unmatched controls who resided in two local government districts in North Cumbria, North West England, from March 1, 1996, to February 29, 2000. Risk was associated with the usual daily volume of cold unboiled tap water drunk (odds ratio [OR] 1.40, 95% confidence intervals [CI] 1.14 to 1.71 per pint consumed per day [p = 0.001]) and short visits to farms (OR 2.02, 95% CI 1.04 to 3.90, p = 0.04). Fifty-six (84%) of 67 fecal specimens from patients obtained from January 1, 1998, and February 29, 2000, were Cryptosporidium parvum genotype 2 (animal and human strain). Livestock fecal pollution of water sources appears to be the leading cause of human sporadic cryptosporidiosis in this population and shows the need for better protection of water catchments from livestock and improved drinking water treatment in this area of England.
1996年3月1日至2000年2月29日期间，在居住于英格兰西北部坎布里亚郡北部两个地方政府辖区的152例患者和466例非匹配对照中，确定了散发性隐孢子虫病的危险因素。风险与日常饮用的未煮沸冷水的通常日饮水量有关（比值比[OR]为1.40，95%置信区间[CI]为每天每品脱饮用量1.14至1.71 [p = 0.001]）以及短期访问农场（OR为2.02，95% CI为1.04至3.90，p = 0.04）。1998年1月1日至2000年2月29日期间从患者获得的67份粪便标本中的56份（84%）为微小隐孢子虫基因型2（动物和人类菌株）。水源的家畜粪便污染似乎是该人群中人类散发性隐孢子虫病的主要原因，这表明在英格兰的该地区需要更好地保护集水区免受家畜污染，并改善饮用水处理。
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