Berahmat Reza, Spotin Adel, Ahmadpour Ehsan, Mahami-Oskouei Mahmoud, Rezamand Azim, Aminisani Nayyereh, Ghojazadeh Morteza, Ghoyounchi Roghayeh, Mikaeili-Galeh Tahereh
Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Parasitol Res. 2017 Apr;116(4):1111-1128. doi: 10.1007/s00436-017-5376-3. Epub 2017 Jan 21.
Cryptosporidiosis caused by Cryptosporidium spp. is an important parasitic disease that can be life-threatening for children and immunocompromised patients. This systematic review and meta-analysis was designed to determine the prevalence rate of Cryptosporidium infection and related risk factors among the Iranian general population. We searched electronic databases including Google Scholar, PubMed, Science Direct, Scopus and Proquest for articles in English and SID, Magiran, IranMedex, and IranDoc for articles in Persian. Out of 4816 studies identified in the electronic search, 94 articles were eligible for inclusion in the systematic review and meta-analysis. The prevalence rate of cryptosporidiosis by using the random effect model among children, healthy people, and gastroenteritis and immunocompromised patients in Iran was estimated as 3.65, 2.94, 1.29, and 4.54%, respectively. Findings of a phylogenetic analysis inferred by gp60 and 18S ribosomal RNA markers indicated that most of the infection rate belonged to C. parvum (particularly subtype IIaA15G2R1) and C. hominis among understudied groups. The present study is the first systematic review and meta-analysis providing a comprehensive view of the prevalence of human cryptosporidiosis and its related risk factors in Iran. It seems that the awareness of Cryptosporidium prevalence, risk factors, and disease complications may be required for developing effective strategies to prevent infection.
由隐孢子虫属引起的隐孢子虫病是一种重要的寄生虫病，对儿童和免疫功能低下的患者可能危及生命。本系统评价和荟萃分析旨在确定伊朗普通人群中隐孢子虫感染的患病率及相关危险因素。我们检索了包括谷歌学术、PubMed、科学Direct、Scopus和Proquest在内的电子数据库以查找英文文章，以及SID、Magiran、IranMedex和IranDoc以查找波斯文文章。在电子检索中识别出的4816项研究中，有94篇文章符合纳入系统评价和荟萃分析的条件。采用随机效应模型估计，伊朗儿童、健康人群、胃肠炎患者和免疫功能低下患者的隐孢子虫病患病率分别为3.65%、2.94%、1.29%和4.54%。通过gp60和18S核糖体RNA标记推断的系统发育分析结果表明，在研究的人群组中，大多数感染率属于微小隐孢子虫（特别是IIaA15G2R1亚型）和人隐孢子虫。本研究是首次对伊朗人类隐孢子虫病患病率及其相关危险因素进行全面综述的系统评价和荟萃分析。为制定有效的感染预防策略，似乎需要了解隐孢子虫的患病率、危险因素和疾病并发症。
