Kim Jin Kook, Kim Sung Soo, Lee Hyung Keun, Lee In Sik, Seong Gong Je, Kim Eung Kweon, Han Sueng Han
Balgensesang Ophthalmology Clinic, Institute of Vision Research, Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, South Korea.
J Cataract Refract Surg. 2004 Jul;30(7):1405-11. doi: 10.1016/j.jcrs.2003.12.053.
To compare the visual and refractive outcomes of laser in situ keratomileusis (LASIK) and laser-assisted subepithelial keratectomy (LASEK) in the treatment of high myopia.
Institute of Vision Research, Department of Ophthalmology, College of Medicine, Yonsei University, and Balgeunsesang Ophthalmology Clinic, Seoul, South Korea.
Four hundred seventy eyes of 240 patients with manifest refraction spherical components greater than -6.00 diopters (D) were assigned to 2 groups: 324 eyes (167 patients) were treated with LASIK and 146 eyes (73 patients), with LASEK. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), remaining refractive error, corneal haze, and complications were followed in both groups for 12 months.
At 12 months, the mean spherical equivalent (SE) was within +/-0.50 D of emmetropia in 205 eyes (63.3%) in the LASIK group and 81 eyes (55.5%) in the LASEK group and within +/-1.00 D in 261 eyes (80.6%) and 104 eyes (71.2%), respectively. The UCVA was 20/25 or better in 269 LASIK eyes (83.0%) and 111 LASEK eyes (76.0%). There was more than a 1-line loss of BSCVA in 4 LASIK eyes (1.2%) and 21 LASEK eyes (14.3%). The between-group differences in SE, magnitude of cylinder, UCVA, and haze were statistically significant (P<.05).
Both LASIK and LASEK were safe and effectively treated eyes with high myopia. Laser in situ keratomileusis provided superior results in visual predictability and corneal opacity.
比较准分子原位角膜磨镶术（LASIK）和准分子激光上皮下角膜磨镶术（LASEK）治疗高度近视的视觉和屈光效果。
韩国首尔延世大学医学院眼科视觉研究所和Balgeunsesang眼科诊所。
将240例明显屈光球镜成分大于-6.00屈光度（D）的患者的470只眼分为两组：324只眼（167例患者）接受LASIK治疗，146只眼（73例患者）接受LASEK治疗。两组均随访12个月，观察裸眼视力（UCVA）、最佳矫正视力（BSCVA）、残余屈光不正、角膜混浊及并发症情况。
12个月时，LASIK组205只眼（63.3%）和LASEK组81只眼（55.5%）的平均球镜等效度（SE）在正视眼的±0.50 D范围内，分别有261只眼（80.6%）和104只眼（71.2%）在±1.00 D范围内。LASIK组269只眼（83.0%）和LASEK组111只眼（76.0%）的UCVA达到20/25或更好。4只LASIK眼（1.2%）和21只LASEK眼（14.3%）的BSCVA下降超过1行。两组在SE、柱镜度数、UCVA和混浊程度方面的差异有统计学意义（P<0.05）。
LASIK和LASEK治疗高度近视均安全有效，但准分子原位角膜磨镶术在视觉可预测性和角膜混浊方面效果更佳。
