Collins William E, Jeffery Geoffrey M, Roberts Jacquelin M
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
Am J Trop Med Hyg. 2004 Jun;70(6):642-4.
A retrospective examination was made of archival data collected between 1940 and 1963 to determine the impact of reinfection of patients with Plasmodium vivax with homologous and heterologous strains of the parasite. Following reinfection of 14 patients with a homologous strain, the geometric mean maximum parasite count was reduced from 9,101/microL during the primary infection to 998/microL and the geometric mean daily parasite count for the first 20 days was reduced from 923/microL to 16/microL. Following reinfection of 22 patients with heterologous strains of P. vivax, the geometric mean maximum parasite count was 8,460/microL during the primary infection versus a secondary level of 9,196/microL and the geometric mean daily parasite count decreased from 847/microL/day to 335/microL/day. Reductions in fever episodes > or =101 degrees F and > or = 104 degrees F appeared to be a more sensitive measure of clinical immunity. Fever episodes > or =104 degrees F in patients with homologous strain reinfections decreased from 1.92 episodes per week to 0.18 compared with 1.24 to 0.57 in patients with heterologous infections. Fever episodes > or =101 degrees F decreased from 2.98 to 0.60 in the homologous strain compared with 2.08 to 1.07 for the heterologous infections. The average maximum fever temperature in the homologous group was 106 degrees F during the primary infection versus 103.4 degrees F for the secondary infection compared with 105.8 degrees F during the primary infections versus 105.6 degrees F for the secondary infection in the heterologous patients.
对1940年至1963年间收集的档案数据进行了回顾性研究，以确定间日疟原虫患者再次感染同源和异源疟原虫菌株的影响。14名患者再次感染同源菌株后，几何平均最大寄生虫计数从初次感染时的9101/微升降至998/微升，前20天的几何平均每日寄生虫计数从923/微升降至16/微升。22名患者再次感染间日疟原虫异源菌株后，初次感染时的几何平均最大寄生虫计数为8460/微升，二次感染时为9196/微升，几何平均每日寄生虫计数从847/微升/天降至335/微升/天。发热发作次数≥101华氏度和≥104华氏度的减少似乎是临床免疫更敏感的指标。同源菌株再次感染患者中≥104华氏度的发热发作次数从每周1.92次降至0.18次，而异源感染患者中则从1.24次降至0.57次。同源菌株中≥101华氏度的发热发作次数从2.98次降至0.60次，而异源感染患者中则从2.08次降至1.07次。同源组初次感染时的平均最高发热温度为106华氏度，二次感染时为103.4华氏度，而异源患者初次感染时为105.8华氏度，二次感染时为105.6华氏度。
