Hodohara K, Fujiyama Y, Inoue T, Niwakawa M, Kitoh K, Andoh A, Bamba T, Hosoda S, Abe T
Second Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan.
Cancer Genet Cytogenet. 1992 Aug;62(1):88-91. doi: 10.1016/0165-4608(92)90045-a.
Trisomy 4 has been identified previously as a chromosome abnormality associated with acute nonlymphocytic leukemia (ANLL) with myelomonocytic lineage and in myelodysplastic syndromes (MDS). We report a case of acute lymphocytic leukemia (ALL) (French-American-British, FAB L1) in a 42-year-old Japanese man, with trisomy 4 as the sole chromosomal anomaly. Immunophenotypically, the leukemic blasts demonstrated reactivity with CD2, CD5, and CD7 and indicated on early stage of T cell.
