小鼠针对新型隐球菌肺部感染产生的抗体具有非保护性抗体的特征。
Antibodies produced in response to Cryptococcus neoformans pulmonary infection in mice have characteristics of nonprotective antibodies.
作者信息
Zaragoza Oscar, Casadevall Arturo
机构信息
Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.
出版信息
Infect Immun. 2004 Jul;72(7):4271-4. doi: 10.1128/IAI.72.7.4271-4274.2004.
Abstract
Murine cryptocococcal pulmonary infection elicited serum immunoglobulin M (IgM) and IgG to the capsular polysaccharide, but only IgG stained yeast cells in alveoli. Both isotypes produced punctuate immunofluorescence patterns on yeast cells like those of nonprotective antibodies. The difficulties involved in associating humoral immunity with protection in murine cryptocococcal infection could reflect nonprotective antibody responses.
摘要
小鼠隐球菌肺部感染可引发针对荚膜多糖的血清免疫球蛋白M（IgM）和IgG，但只有IgG能对肺泡中的酵母细胞进行染色。这两种同种型在酵母细胞上产生的点状免疫荧光模式与非保护性抗体的模式相似。在小鼠隐球菌感染中，将体液免疫与保护作用联系起来所涉及的困难可能反映了非保护性抗体反应。
相似文献
1
Antibodies produced in response to Cryptococcus neoformans pulmonary infection in mice have characteristics of nonprotective antibodies.小鼠针对新型隐球菌肺部感染产生的抗体具有非保护性抗体的特征。
Infect Immun. 2004 Jul;72(7):4271-4. doi: 10.1128/IAI.72.7.4271-4274.2004.
2
Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles.针对新型隐球菌葡糖醛酸木聚糖甘露聚糖的保护性和非保护性人免疫球蛋白M单克隆抗体表现出不同的特异性和基因使用谱。
Infect Immun. 2004 Aug;72(8):4810-8. doi: 10.1128/IAI.72.8.4810-4818.2004.
3
Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell.源自单个B细胞的新型隐球菌保护性和非保护性单克隆抗体。
J Exp Med. 1995 Jan 1;181(1):405-9. doi: 10.1084/jem.181.1.405.
4
B cell response during infection with the MAT a and MAT alpha mating types of Cryptococcus neoformans.新型隐球菌MAT a和MATα交配型感染期间的B细胞反应。
Microbes Infect. 2005 Jan;7(1):118-25. doi: 10.1016/j.micinf.2004.09.009. Epub 2004 Nov 26.
5
Both Th1 and Th2 cytokines affect the ability of monoclonal antibodies to protect mice against Cryptococcus neoformans.Th1和Th2细胞因子均会影响单克隆抗体保护小鼠抵御新型隐球菌的能力。
Infect Immun. 2001 Oct;69(10):6445-55. doi: 10.1128/IAI.69.10.6445-6455.2001.
6
Isotype switching increases efficacy of antibody protection against Cryptococcus neoformans infection in mice.同种型转换增强了抗体对小鼠新型隐球菌感染的保护效力。
Infect Immun. 1998 Mar;66(3):1057-62. doi: 10.1128/IAI.66.3.1057-1062.1998.
7
Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells.抗体介导的针对新型隐球菌肺部感染的保护作用依赖于B细胞。
Infect Immun. 2005 Feb;73(2):1141-50. doi: 10.1128/IAI.73.2.1141-1150.2005.
8
9
Immunoglobulin G3 blocking antibodies to the fungal pathogen Cryptococcus neoformans.针对真菌病原体新型隐球菌的免疫球蛋白G3阻断抗体。
J Exp Med. 1996 Apr 1;183(4):1905-9. doi: 10.1084/jem.183.4.1905.
10
Characterization of immunoglobulin classes of human antibodies to cryptococcus neoformans.人抗新型隐球菌抗体免疫球蛋白类别的鉴定
Mycopathologia. 1977 Jul 29;61(1):55-60. doi: 10.1007/BF00440759.
引用本文的文献
1
The capsule of .胶囊的 。
Virulence. 2019 Dec;10(1):822-831. doi: 10.1080/21505594.2018.1431087. Epub 2018 Aug 1.
2
The role of Aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy.天冬氨酰氨肽酶（Ape4）在新型隐球菌毒力和自噬中的作用。
PLoS One. 2017 May 25;12(5):e0177461. doi: 10.1371/journal.pone.0177461. eCollection 2017.
3
Vaccines for invasive fungal infections.侵袭性真菌感染的疫苗。
F1000 Med Rep. 2011;3:13. doi: 10.3410/M3-13. Epub 2011 Jul 1.
4
Evaluation of Cryptococcus neoformans galactoxylomannan-protein conjugate as vaccine candidate against murine cryptococcosis.评估新型隐球菌半乳甘露聚糖-蛋白结合物作为抗鼠隐球菌病疫苗候选物。
Vaccine. 2011 Feb 24;29(10):1891-8. doi: 10.1016/j.vaccine.2010.12.134. Epub 2011 Jan 14.
5
Capsule structural heterogeneity and antigenic variation in Cryptococcus neoformans.新型隐球菌的荚膜结构异质性和抗原变异
Eukaryot Cell. 2007 Aug;6(8):1464-73. doi: 10.1128/EC.00162-07. Epub 2007 Jun 29.
6
The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans infection is associated with pleiotropic differences in the immune response.小鼠品系对肺部新型隐球菌感染的相对易感性与免疫反应中的多效性差异有关。
Infect Immun. 2007 Jun;75(6):2729-39. doi: 10.1128/IAI.00094-07. Epub 2007 Mar 19.
7
Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells.抗体介导的针对新型隐球菌肺部感染的保护作用依赖于B细胞。
Infect Immun. 2005 Feb;73(2):1141-50. doi: 10.1128/IAI.73.2.1141-1150.2005.
8
Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity.用Als1p重组N端结构域进行疫苗接种，通过增强细胞介导而非体液免疫，提高小鼠播散性念珠菌病的存活率。
Infect Immun. 2005 Feb;73(2):999-1005. doi: 10.1128/IAI.73.2.999-1005.2005.
本文引用的文献
1
The efficacy of complement-mediated phagocytosis of Cryptococcus neoformans is dependent on the location of C3 in the polysaccharide capsule and involves both direct and indirect C3-mediated interactions.补体介导的新型隐球菌吞噬作用的效力取决于C3在多糖荚膜中的位置，并且涉及直接和间接的C3介导的相互作用。
Eur J Immunol. 2003 Jul;33(7):1957-67. doi: 10.1002/eji.200323848.
2
More is not necessarily better: prozone-like effects in passive immunization with IgG.更多并不一定更好：IgG被动免疫中的前带样效应。
J Immunol. 2003 Apr 1;170(7):3621-30. doi: 10.4049/jimmunol.170.7.3621.
3
Induced humoral immunity and vaccination against major human fungal pathogens.诱导性体液免疫与针对主要人类真菌病原体的疫苗接种
Curr Opin Microbiol. 2002 Aug;5(4):386-91. doi: 10.1016/s1369-5274(02)00337-5.
4
CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans.补体受体3（CR3，CD11b/CD18）和补体受体4（CR4，CD11c/CD18）参与不依赖补体的抗体介导的新型隐球菌吞噬作用。
Immunity. 2002 Jun;16(6):791-802. doi: 10.1016/s1074-7613(02)00328-x.
5
Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection.新型隐球菌在小鼠肺部感染过程中的形态动态变化。
Microbiology (Reading). 2001 Aug;147(Pt 8):2355-2365. doi: 10.1099/00221287-147-8-2355.
6
Immunoregulation by capsular components of Cryptococcus neoformans.新型隐球菌荚膜成分的免疫调节作用
Med Mycol. 2000 Dec;38(6):407-17. doi: 10.1080/mmy.38.6.407.417.
7
Capsular reactions of Cryptococcus neoformans with polyspecific and oligospecific polyclonal anticapsular antibodies.新型隐球菌与多特异性和寡特异性多克隆抗荚膜抗体的荚膜反应
Infect Immun. 2001 Feb;69(2):1189-91. doi: 10.1128/IAI.69.2.1189-1191.2001.
8
Biological correlates of capsular (quellung) reactions of Cryptococcus neoformans.新型隐球菌荚膜（荚膜肿胀）反应的生物学关联。
J Immunol. 2000 May 1;164(9):4835-42. doi: 10.4049/jimmunol.164.9.4835.
9
A human IgM monoclonal antibody prolongs survival of mice with lethal cryptococcosis.一种人源IgM单克隆抗体可延长患有致命性隐球菌病小鼠的生存期。
J Infect Dis. 1998 Oct;178(4):1213-6. doi: 10.1086/515688.
Zotero 插件