CE-MC：一个多蛋白质结构比对服务器。
CE-MC: a multiple protein structure alignment server.
作者信息
Guda Chittibabu, Lu Sifang, Scheeff Eric D, Bourne Philip E, Shindyalov Ilya N
机构信息
San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
出版信息
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W100-3. doi: 10.1093/nar/gkh464.
Abstract
CE-MC server (http://cemc.sdsc.edu) provides a web-based facility for the alignment of multiple protein structures based on C-alpha coordinate distances, using combinatorial extension (CE) and Monte Carlo (MC) optimization methods. Alignments are possible for user-selected PDB (Protein Data Bank) chains as well as for user-uploaded structures or the combination of the two. The whole process of generating multiple structure alignments involves three distinct steps, i.e. all-to-all pairwise alignment using the CE algorithm, iterative global optimization of a multiple alignment using the MC algorithm and formatting MC results using the JOY program. The server can be used to get multiple alignments for up to 25 protein structural chains with the flexibility of uploading multiple coordinate files and performing multiple structure alignment for user-selected PDB chains. For large-scale jobs and local installation of the CE-MC program, users can download the source code and precompiled binaries from the web server.
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