Mahajan Prashant, Haritos Demetris, Rosenberg Norman, Thomas Ronald
Division of Pediatric Emergency Medicine, Children's Hospital of Michigan, Detroit, Michigan, USA.
J Emerg Med. 2004 Jul;27(1):21-5. doi: 10.1016/j.jemermed.2004.02.006.
A prospective, randomized, double blinded study was conducted to determine whether a combination of nebulized magnesium sulfate and albuterol as a single dose adds any benefit in management of children with mild to moderate asthma when compared to nebulized albuterol with saline. The difference in FEV1 was significant at 10 and 20 min after a single dose of the combined treatment with magnesium and albuterol when compared with the albuterol and saline group (1.41 L +/- 0.53 vs. 1.13 L +/- 0.34, respectively, p = 0.03). The addition of magnesium to albuterol seems to provide short-term benefits in children with acute exacerbations of mild to moderate asthma.
进行了一项前瞻性、随机、双盲研究，以确定与雾化沙丁胺醇加生理盐水相比，雾化硫酸镁和沙丁胺醇单剂量联合使用在治疗轻度至中度哮喘儿童时是否能带来任何益处。与沙丁胺醇和生理盐水组相比，在单次联合使用镁和沙丁胺醇治疗后10分钟和20分钟时，第一秒用力呼气量（FEV1）的差异具有统计学意义（分别为1.41升±0.53与1.13升±0.34，p = 0.03）。在沙丁胺醇中添加镁似乎能为轻度至中度哮喘急性加重的儿童提供短期益处。
