Intrinsic factor-mediated modulation of cyanocobalamin-N-sulfonyl-acridinium-9-carboxamide chemiluminescence.
作者信息
Adamczyk Maciej, Johnson Donald D, Mattingly Phillip G, Moore Jeffrey A, Pan You
机构信息
Department of Chemistry (D09MD), Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, AP20, Abbott Park, IL 60064-6016, USA.
出版信息
Bioorg Med Chem Lett. 2004 Aug 2;14(15):3917-21. doi: 10.1016/j.bmcl.2004.05.062.
PMID:15225697
Abstract
Two cyanocobalamin-N-sulfonyl-acridinium-9-carboxamides with linkage through the N(10) or 9-position were prepared from B(12)-e-carboxylic acid. The noncovalent association of intrinsic factor with these ligands resulted in specific modulation of the associated chemiluminescence signal either by quenching or changing the emission profile. Either effect was sufficient to formulate a homogeneous assay to detect vitamin B(12) in buffer.
摘要
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