一种利用磁共振图像对婴儿髓鞘形成发育进行的定量测量方法。
A quantitative measure of myelination development in infants, using MR images.
作者信息
Carmody Dennis P, Dunn Stanley M, Boddie-Willis Akiza S, DeMarco J Kevin, Lewis Michael
机构信息
Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.
出版信息
Neuroradiology. 2004 Sep;46(9):781-6. doi: 10.1007/s00234-004-1241-z.
The objective of this study was to measure myelination of frontal lobe changes in infants and young children. Twenty-four cases of infants and children (age range 12-121 months) were evaluated by a quantitative assessment of T2-weighted MR image features. Reliable quantitative changes between white and gray matter correlated with developmental age in a group of children with no neurological findings. Myelination appears to be an increasing exponential function with the greatest rate of change occurring over the first 3 years of life. The quantitative changes observed were in accordance with previous qualitative judgments of myelination development. Children with periventricular leukomalacia (PVL) showed delays in achieving levels of myelination when compared to normal children and adjusted for chronological age. The quantitative measure of myelination development may prove to be useful in assessing the stages of development and helpful in the quantitative descriptions of white matter disorders such as PVL.
本研究的目的是测量婴幼儿额叶髓鞘形成的变化。通过对24例婴幼儿（年龄范围为12 - 121个月）的T2加权磁共振图像特征进行定量评估。在一组无神经学异常的儿童中，白质和灰质之间可靠的定量变化与发育年龄相关。髓鞘形成似乎是一个呈指数增长的函数，在生命的头3年变化率最大。观察到的定量变化与先前对髓鞘形成发育的定性判断一致。与正常儿童相比，经实足年龄校正后，患有脑室周围白质软化症（PVL）的儿童在达到髓鞘形成水平方面存在延迟。髓鞘形成发育的定量测量可能被证明在评估发育阶段以及对白质疾病如PVL进行定量描述方面是有用的。
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