Martorell Edgar A, Murray Peter M, Peterson Jeffrey J, Menke David M, Calamia Kenneth T
Department of Internal Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
J Hand Surg Am. 2004 Jul;29(4):654-60. doi: 10.1016/j.jhsa.2004.04.012.
Palmar fasciitis and polyarthritis syndrome (PFPAS) is an uncommon paraneoplastic syndrome associated with several malignant neoplasms. We identified 4 patients with PFPAS and ovarian carcinoma. Palmar fasciitis, at times severe, and inflammatory polyarthritis dominated the clinical presentation in all 4 patients. In 3 of our 4 patients the presentation of palmar fasciitis and inflammatory polyarthritis preceded the diagnosis of ovarian carcinoma. Magnetic resonance scanning and biopsy examination of palmar nodules in one patient revealed findings of inflammation and fibrosis. A literature review found 10 other cases of PFPAS associated with ovarian carcinoma. Improvement in palmar fasciitis and inflammatory arthritis often occurs after successful treatment of the ovarian carcinoma. Digital contractures, however, can persist. We recommend a gynecologic examination in any woman presenting with the sudden onset of unexplained hand pain, palmar inflammatory fasciitis, palmar fibromatosis, and digital contractures.
掌腱膜挛缩症和多关节炎综合征（PFPAS）是一种与多种恶性肿瘤相关的罕见副肿瘤综合征。我们确定了4例患有PFPAS和卵巢癌的患者。掌腱膜挛缩症，有时较为严重，以及炎性多关节炎是所有4例患者的主要临床表现。在我们的4例患者中，有3例掌腱膜挛缩症和炎性多关节炎的表现先于卵巢癌的诊断。对1例患者的掌部结节进行磁共振扫描和活检检查，发现有炎症和纤维化的表现。文献综述发现另外10例PFPAS与卵巢癌相关。卵巢癌成功治疗后，掌腱膜挛缩症和炎性关节炎通常会有所改善。然而，手指挛缩可能会持续存在。我们建议，对于任何出现不明原因手部疼痛、掌部炎性腱膜挛缩症、掌部纤维瘤病和手指挛缩突然发作的女性，都应进行妇科检查。
