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硬结性网状掌部红斑作为副肿瘤性掌筋膜挛缩症和多关节炎综合征的体征。

Indurated reticulate palmar erythema as a sign of paraneoplastic palmar fasciitis and polyarthritis syndrome.

作者信息

Preda Veronica A, Frederiksen Peter, Kossard Steven

机构信息

Skin & Cancer Foundation, Darlinghurst, NSW, Australia.

出版信息

Australas J Dermatol. 2009 Aug;50(3):198-201. doi: 10.1111/j.1440-0960.2009.00538.x.

Abstract

A 62-year-old woman presented with a 6-month history of polyarthritis. She had also noted a 2-month history of indurated palmar erythema and increasing bilateral hand swelling and stiffness. A biopsy from the area of palmar erythema showed interstitial fibroplasia within the dermis and subcutis representing a palmar fibromatosis. This presentation appears to belong to the spectrum of palmar fasciitis and polyarthritis syndrome. Rheumatologists have recognised this syndrome as a paraneoplastic disorder and subsequent investigations in our patient revealed an elevated cancer antigen 125 and an inoperable ovarian carcinoma. Indurated palmar erythema is a sign that is not widely recognised by dermatologists as a clue for this paraneoplastic syndrome, and skin biopsy demonstrating dermal and subcutaneous fibroplasia may help in diagnosis in the absence of advanced signs of palmar fasciitis.

摘要

一名62岁女性,有6个月的多关节炎病史。她还注意到有2个月的手掌硬结性红斑病史,且双侧手部肿胀和僵硬情况日益加重。手掌红斑部位的活检显示真皮和皮下组织存在间质纤维化,提示为掌部纤维瘤病。这种表现似乎属于掌腱膜筋膜炎和多关节炎综合征范畴。风湿病学家已将该综合征识别为一种副肿瘤性疾病,对我们这位患者随后的检查发现癌抗原125升高以及无法手术切除的卵巢癌。硬结性手掌红斑这一体征未被皮肤科医生广泛认可为这种副肿瘤综合征的线索,而在没有掌腱膜筋膜炎晚期体征的情况下,皮肤活检显示真皮和皮下纤维化可能有助于诊断。

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