Finkelstein J N, Horowitz S, Sinkin R A, Ryan R M
Department of Pediatrics (Neonatology), Strong Children's Research Center, Rochester, New York.
Clin Perinatol. 1992 Sep;19(3):603-20.
Those factors that determine whether tissue injury is followed by regeneration and repair or irreversible destruction and fibrosis are only now being elucidated. This article examines the lung's response to injury, the prominent role of polypeptide growth factors and cytokines in directing tissue responses, and the effects of injury on cell-specific expression of a number of genes.
那些决定组织损伤后是发生再生和修复还是不可逆破坏及纤维化的因素,直到现在才得以阐明。本文探讨了肺对损伤的反应、多肽生长因子和细胞因子在指导组织反应中的突出作用,以及损伤对许多基因细胞特异性表达的影响。