Speer C P
Department of Pediatrics, University Children's Hospital, Würzburg, Germany.
J Perinatol. 2006 May;26 Suppl 1:S57-62; discussion S63-4. doi: 10.1038/sj.jp.7211476.
Various pre- and postnatal risk factors, which act additively or synergistically induce an injurious inflammatory response in the airways and the pulmonary interstitium of preterm infants with bronchopulmonary dysplasia. This inflammatory response is characterized by an accumulation of neutrophils and macrophages as well as an arsenal of proinflammatory mediators that affect the endothelium and alveolar-capillary integrity. Besides proinflammatory cytokines and toxic oxygen radicals, lipid mediators as well as potent proteases may be responsible for acute lung injury. There is increasing evidence that an imbalance between pro- and anti-inflammatory factors, which should protect the alveoli and lung tissue, are key features in the pathogenesis of bronchopulmonary dysplasia. In addition, a subnormal generation of growth factors may affect alveolarization and vascular development in preterm infants with bronchopulmonary dysplasia. In this condensed review article, the current concepts on the possible role of inflammation in the evolution of bronchopulmonary dysplasia will be summarized.
各种产前和产后危险因素，以相加或协同的方式作用，在患有支气管肺发育不良的早产儿的气道和肺间质中引发有害的炎症反应。这种炎症反应的特征是中性粒细胞和巨噬细胞的积聚，以及一系列影响内皮细胞和肺泡-毛细血管完整性的促炎介质。除了促炎细胞因子和有毒氧自由基外，脂质介质以及强效蛋白酶可能是急性肺损伤的原因。越来越多的证据表明，在支气管肺发育不良的发病机制中，应保护肺泡和肺组织的促炎和抗炎因子之间的失衡是关键特征。此外，生长因子生成不足可能会影响患有支气管肺发育不良的早产儿的肺泡化和血管发育。在这篇综述文章中，将总结关于炎症在支气管肺发育不良演变中可能作用的当前概念。
