Altan-Bonnet Nihal, Sougrat Rachid, Lippincott-Schwartz Jennifer
Cell biology and Metabolism Branch, National Institutes of Child Health and Development, National Institutes of Health, Bethesda, Maryland, MD 20892, USA.
Curr Opin Cell Biol. 2004 Aug;16(4):364-72. doi: 10.1016/j.ceb.2004.06.011.
The Golgi apparatus contains thousands of different types of integral and peripheral membrane proteins, perhaps more than any other intracellular organelle. To understand these proteins' roles in Golgi function and in broader cellular processes, it is useful to categorize them according to their contribution to Golgi creation and maintenance. This is because all of the Golgi's functions derive from its ability to maintain steady-state pools of particular proteins and lipids, which in turn relies on the Golgi's dynamic character - that is, its ongoing state of transformation and outgrowth from the endoplasmic reticulum. Here, we categorize the expanding list of Golgi-associated proteins on the basis of their role in Golgi reformation after the Golgi has been disassembled. Information gained on how different proteins participate in this process can provide important insights for understanding the Golgi's global functions within cells.
高尔基体包含数千种不同类型的整合膜蛋白和外周膜蛋白，可能比任何其他细胞内细胞器都多。为了了解这些蛋白质在高尔基体功能和更广泛的细胞过程中的作用，根据它们对高尔基体形成和维持的贡献对其进行分类是很有用的。这是因为高尔基体的所有功能都源于其维持特定蛋白质和脂质稳态池的能力，而这又依赖于高尔基体的动态特性——即它从内质网不断转变和生长的状态。在这里，我们根据高尔基体解体后它们在高尔基体重塑中的作用，对不断增加的与高尔基体相关的蛋白质列表进行分类。关于不同蛋白质如何参与这一过程的信息，可为理解高尔基体在细胞内的整体功能提供重要见解。
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