Aigner Thomas, Saas Joachim, Zien Alexander, Zimmer Ralf, Gebhard Pia M, Knorr Thomas
Cartilege Research, Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany.
Methods Mol Med. 2004;100:109-28. doi: 10.1385/1-59259-810-2:109.
The regulation of chondrocytes in osteoarthritic cartilage and the expression of specific gene products by these cells during early-onset and late-stage osteoarthritis are not well characterized. With the introduction of cDNA array technology, the measurement of thousands of different genes in one small tissue sample can be carried out. Interpretation of gene expression analyses in articular cartilage is aided by the fact that this tissue contains only one cell type in both normal and diseased conditions. However, care has to be taken not to over- and misinterpret results, and some major challenges must be overcome in order to utilize the potential of this technology properly in the field of osteoarthritis.
