胰岛素样生长因子1与肌肉生长：对卫星细胞增殖的影响

Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation.

作者信息

Machida Shuichi, Booth Frank W

机构信息

Department of Biomedical Sciences, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA.

出版信息

Proc Nutr Soc. 2004 May;63(2):337-40. doi: 10.1079/PNS2004354.

DOI:10.1079/PNS2004354

PMID:15294052

Abstract

Insulin-like growth factor 1 (IGF-1) has been shown to rescue the aging-related or inactivity-induced loss of muscle mass through the activation of satellite cells. However, the signalling pathways and the mechanism by which IGF-1 affects satellite cells have not been not completely identified. The purpose of the present review is to provide current understanding of the cellular and molecular events underlying IGF-1 induced proliferation of satellite cells.

摘要

胰岛素样生长因子1（IGF-1）已被证明可通过激活卫星细胞来挽救与衰老相关或因缺乏运动引起的肌肉量损失。然而，IGF-1影响卫星细胞的信号通路和机制尚未完全明确。本综述的目的是阐述目前对IGF-1诱导卫星细胞增殖背后的细胞和分子事件的理解。