劳吉尔-洪齐克尔综合征中结膜和阴茎的额外色素沉着：两例报告
Additional conjunctival and penile pigmentation in Laugier-Hunziker syndrome: a report of two cases.
作者信息
Ayoub Nakhlé, Barete Stéphane, Bouaziz Jean-David, Le Pelletier François, Frances Camille
机构信息
Dermatology Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
出版信息
Int J Dermatol. 2004 Aug;43(8):571-4. doi: 10.1111/j.1365-4632.2004.02173.x.
BACKGROUND
Laugier-Hunziker syndrome is a rare acquired hyperpigmentation of the oral mucosa and lips which is often associated with longitudinal melanonychia. We report two patients exhibiting the classical features of Laugier-Hunziker syndrome with additional and previously unreported conjunctival and penile pigmentation.
PATIENTS AND METHODS
Two patients presented with a history of progressive acquired macular pigmentation of the oral mucosa, the lips, the ocular conjunctiva and the penis. Longitudinal melanonychia was found in one patient. Microscopic features (basal epithelial melanosis, moderate acanthosis and superficial pigmentary incontinence) and ultrastructural details (increased number of normal-appearing melanosomes inside basal keratinocytes and dermal melanophages) were characteristic of Laugier-Hunziker syndrome.
CONCLUSIONS
These two observations illustrate the topographical variations of Laugier-Hunziker syndrome and highlight the need to expand the originally described features to include more widespread areas of hyperpigmentation.
背景
劳吉尔-杭齐克尔综合征是一种罕见的后天性口腔黏膜和唇部色素沉着过度疾病，常伴有甲纵嵴黑甲。我们报告了两名表现出劳吉尔-杭齐克尔综合征典型特征的患者，其结膜和阴茎出现了额外的、此前未报告过的色素沉着。
患者与方法
两名患者均有口腔黏膜、唇部、眼结膜和阴茎进行性后天性斑片状色素沉着病史。其中一名患者发现有甲纵嵴黑甲。微观特征（基底上皮黑素沉着、中度棘层肥厚和浅表色素失禁）和超微结构细节（基底角质形成细胞和真皮黑素细胞内外观正常的黑素小体数量增加）是劳吉尔-杭齐克尔综合征的特征。
结论
这两例观察结果说明了劳吉尔-杭齐克尔综合征的部位变异情况，并强调有必要扩大最初描述的特征范围，以纳入更广泛的色素沉着过度区域。
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