抗抑郁反应的药物遗传学。
Pharmacogenetics of antidepressant response.
机构信息
Institute of Psychiatry, University of Bologna, Bologna, Italy.
出版信息
J Psychiatry Neurosci. 2011 Mar;36(2):87-113. doi: 10.1503/jpn.100059.
Abstract
Personalized medicine - the adaptation of therapies based on an individual's genetic and molecular profile - is one of the most promising aspects of modern medicine. The identification of the relation between genotype and drug response, including both the therapeutic effect and side effect profile, is expected to deeply affect medical practice. In this paper, we review the current knowledge about the genes related to antidepressant treatment response and provide methodologic proposals for future studies. We have mainly focused on genes associated with pharmacodynamics, for which a list of promising genes has been identified despite some inconsistency across studies. We have also synthesized the main results for pharmacokinetic genes, although so far they seem less relevant than those for pharmaco dynamic genes. We discuss possible reasons for these inconsistent findings and propose new study designs.
摘要
个性化医学——根据个体的遗传和分子特征来调整治疗方法——是现代医学最有前途的领域之一。基因型与药物反应之间关系的鉴定，包括治疗效果和副作用特征，预计将对医学实践产生深远影响。本文综述了目前关于与抗抑郁治疗反应相关的基因的知识，并为未来的研究提供了方法学建议。我们主要关注与药效学相关的基因，尽管在不同的研究中存在一些不一致，但已经确定了一系列有希望的基因。我们还综合了药物动力学基因的主要结果，尽管到目前为止，它们似乎不如药效动力学基因那么相关。我们讨论了这些不一致发现的可能原因，并提出了新的研究设计。
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