Buehl Wolf, Menapace Rupert, Sacu Stefan, Kriechbaum Katharina, Koeppl Christina, Wirtitsch Matthias, Georgopoulos Michael, Findl Oliver
Department of Ophthalmology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
J Cataract Refract Surg. 2004 Aug;30(8):1661-7. doi: 10.1016/j.jcrs.2004.02.051.
To compare the inhibiting effect on posterior capsule opacification (PCO) of a silicone intraocular lens (IOL) with a sharp posterior optic edge (ClariFlex OptiEdge, Advanced Medical Optics) and a silicone IOL with a round optic edge (PhacoFlex SI-40, Advanced Medical Optics).
Department of Ophthalmology, University of Vienna, Vienna, Austria.
This prospective randomized patient- and examiner-masked study comprised 104 eyes of 52 patients with bilateral age-related cataract. All patients had cataract surgery in both eyes and received a sharp-edged IOL in 1 eye and a round-edged IOL in the other eye. Postoperative examinations were at 1 week, 1 and 6 months, and 1 year. Digital slitlamp and retroillumination images were taken of each eye. The amount of PCO was assessed subjectively at the slitlamp and objectively using Automated Quantification of After-Cataract (AQUA) automated-image analysis software.
The sharp-edged IOL group had significantly less regeneratory and fibrotic PCO 1 month, 6 months, and 1 year after surgery. The mean AQUA PCO score (scale 0 to 10) was 0.71 in the sharp-edged IOL group and 1.40 in the round-edged IOL group (P<.001). The sharp-edged IOL group had less peripheral fibrotic PCO. There was no significant difference between the 2 IOL groups in patient reports of edge glare.
The sharp-edged design of the ClariFlex OptiEdge silicone IOL led to significantly less PCO than the round-edged PhacoFlex SI-40 IOL 1 year postoperatively.
比较具有锐利后光学边缘的硅酮人工晶状体（IOL）（ClariFlex OptiEdge，Advanced Medical Optics）和具有圆形光学边缘的硅酮IOL（PhacoFlex SI-40，Advanced Medical Optics）对后囊膜混浊（PCO）的抑制效果。
奥地利维也纳大学眼科。
这项前瞻性随机、患者和检查者双盲研究纳入了52例双侧年龄相关性白内障患者的104只眼。所有患者双眼均接受白内障手术，一只眼植入锐利边缘IOL，另一只眼植入圆形边缘IOL。术后检查时间点为1周、1个月、6个月和1年。对每只眼进行数字裂隙灯和后照法图像采集。在裂隙灯下主观评估PCO的程度，并使用白内障后囊膜自动定量（AQUA）自动图像分析软件进行客观评估。
锐利边缘IOL组在术后1个月、6个月和1年时，再生性和纤维化PCO明显较少。锐利边缘IOL组的平均AQUA PCO评分（0至10分）为0.71，圆形边缘IOL组为1.40（P<0.001）。锐利边缘IOL组的周边纤维化PCO较少。两组IOL在患者报告的边缘眩光方面无显著差异。
ClariFlex OptiEdge硅酮IOL的锐利边缘设计在术后1年导致的PCO明显少于圆形边缘的PhacoFlex SI-40 IOL。
