Semple Scott I K, Gilbert Fiona J, Redpath Thomas W, Staff Roger T, Ahearn Trevor S, Welch Andrew E, Heys Steven D, Hutcheon Andrew W, Smyth Elizabeth H, Chaturvedi Shailesh
Department of Radiology, University of Aberdeen, Lilian Sutton Building, AB252ZD Aberdeen, Scotland, UK.
Eur Radiol. 2004 Nov;14(11):2038-45. doi: 10.1007/s00330-004-2454-6. Epub 2004 Aug 14.
The objective of this study was to investigate the relationship between vascular and metabolic characteristics of breast tumours in vivo, using contrast-enhanced dynamic MRI and 2-[(18)F] fluoro-2-deoxy- d-glucose (FDG) PET imaging. Twenty patients with large or locally advanced primary breast cancers were imaged prior to therapy. MRI data were acquired using a dynamic gradient echo sequence and analysed using two pharmacokinetic models. Static PET data were acquired in 2D mode. A significant association ( P<0.05) was observed between the calculated exchange rate constants of both pharmacokinetic models and calculated PET FDG dose uptake ratios (DUR). Statistical analysis showed that the exchange rate constants can explain between 27 and 44% of the variance observed in the PET FDG uptake ratios. A relationship was demonstrated between the vascular and metabolic characteristics of primary breast tumours showing that any assessment of tumour metabolic activity using PET may be controlled at least in part by delivery of uptake agent due to the vascular characteristics of the tumour. MRI and PET provide methods of assessing breast tumour vascularity and metabolism in vivo using the exchange rate constants of dynamic MRI, and DUR of PET, respectively, these measures being related but not equivalent.
本研究的目的是利用对比增强动态磁共振成像（MRI）和2-[(18)F]氟-2-脱氧-d-葡萄糖（FDG）正电子发射断层扫描（PET）成像，在体内研究乳腺肿瘤的血管和代谢特征之间的关系。20例患有大的或局部晚期原发性乳腺癌的患者在治疗前接受了成像检查。使用动态梯度回波序列采集MRI数据，并使用两种药代动力学模型进行分析。以二维模式采集静态PET数据。在两种药代动力学模型的计算交换率常数与计算得到的PET FDG剂量摄取率（DUR）之间观察到显著相关性（P<0.05）。统计分析表明，交换率常数可以解释PET FDG摄取率中观察到的27%至44%的方差。原发性乳腺肿瘤的血管和代谢特征之间的关系得到了证实，这表明使用PET对肿瘤代谢活性的任何评估可能至少部分受肿瘤血管特征导致的摄取剂递送的控制。MRI和PET分别提供了利用动态MRI的交换率常数和PET的DUR在体内评估乳腺肿瘤血管生成和代谢的方法，这些测量方法相关但不等同。
