Toot Jonathan, Dunphy Gail, Turner Monte, Ely Daniel
Biology Department, The University of Akron, Akron, OH 44325-3908, USA.
Behav Genet. 2004 Sep;34(5):515-24. doi: 10.1023/B:BEGE.0000038489.82589.6f.
The Spontaneously Hypertensive Rat (SHR) model was used to test the hypothesis that a locus on the SHR Y-chromosome is responsible for increased aggression resulting from increased serum testosterone and decreased amygdala serotonin content compared to the WKY Y-chromosome. To examine the Y-chromosome in SHR and WKY males, consomic Y-chromosome strains were used (WKY.SHR-Y and SHR.WKY-Y). Novel resident intruder tests and intra-colony scarring behavioral paradigms were used to measure aggression in a colony environment. Both resident intruder test attack number and wounding, along with intra-colony scarring scores showed the colony males with the SHR Y-chromosome (SHR and WKY.SHR-Y strains) were more aggressive than the colony males with the WKY Y-chromosome (WKY and SHR.WKY-Y strains). The SHR Y-chromosome colony male animals also had significantly higher serum testosterone, as well as overall lower amygdala serotonin content than the WKY Y-chromosome colony male animals. The results suggest that these behavioral and physiological differences between the SHR and WKY strains are a result of a mutation in the non-pseudoautosomal region unique to the Y-chromosome.
采用自发性高血压大鼠（SHR）模型来检验以下假设：与WKY Y染色体相比，SHR Y染色体上的一个基因座导致血清睾酮增加和杏仁核5-羟色胺含量降低，从而引发攻击性增强。为了研究SHR和WKY雄性大鼠的Y染色体，使用了染色体代换Y染色体品系（WKY.SHR-Y和SHR.WKY-Y）。采用新颖的定居者-入侵者测试和群体内疤痕行为范式来测量群体环境中的攻击性。定居者-入侵者测试中的攻击次数和致伤情况，以及群体内疤痕评分均显示，具有SHR Y染色体的群体雄性大鼠（SHR和WKY.SHR-Y品系）比具有WKY Y染色体的群体雄性大鼠（WKY和SHR.WKY-Y品系）更具攻击性。与具有WKY Y染色体的群体雄性动物相比，具有SHR Y染色体的群体雄性动物血清睾酮水平也显著更高，而杏仁核5-羟色胺的总体含量更低。结果表明，SHR和WKY品系之间的这些行为和生理差异是Y染色体特有的非假常染色体区域发生突变的结果。
